TABLE 4

Maternal Methadone Doses and Concentrations of Methadone in Maternal Plasma, Breast Milk, and Infant Plasma on Day 14 According to Subject and Group

Patient No.GroupMaternal Methadone Dose, mgMethadone Concentration, ng/mLNAS Treatment
Maternal Plasma, Trough/PeakBreast Milk Before Feeding, Trough/PeakBreast Milk After Feeding, Trough/PeakInfant Plasma
1Breastfed50351/65361.6/115.0105.2/61.93.0aNo
2Formula-fed50356/5102.3aNo
3Breastfed80139/38260.5/122.6208.9/226.22.5aNo
4Formula-fed75567/9392.2No
5Breastfed105270/70962.9/66.7156.2/184.62.4No
6Formula-fed100528/4043.2No
7Breastfed80207/433208.7/242.5226.8/235.64.5aNo
8Formula-fed80319/5722.4aYes
9Breastfed65487/643188.0/287.9367.1/462.02.8aNo
10Formula-fed75185/4442.7Yes
11Breastfed60147/358122.4/78.5192.6/146.62.6No
12Formula-fed65484/7742.4No
13Breastfed70288/425120.3/87.2251.5/257.28.1No
14Formula-fed70134/3212.4Yes
15Breastfed60416/567257.9/335.6171.3/303.82.4aYes
16Formula-fed65227/4092.2Yes
  • NAS treatment indicates requirement for pharmacologic treatment of NAS for the infant after birth (yes or no).

  • a Reconstituted sample.