TABLE 3

Concentrations of Methadone in Breast Milk, Mean Ingestible Infant Doses, and Median Breast Milk/Plasma Methadone Concentration Ratios

Sampling PeriodnBreast Milk Methadone Concentration, ng/mLIngestible Infant Dose, Mean, mg/dMedian Breast Milk/Plasma Methadone Concentration Ratio
Median (Interquartile Range)Range
Day 10.004
    Trough
        Prefeeding467.0 (77.5)40.0–179.00.92
        Postfeeding248.5 (23.0)37.1–60.30.34
    Peak
        Prefeeding298.0 (68.0)63.6–132.20.47
        Postfeeding2115.0 (10.0)109.5–120.00.46
Day 20.012
    Trough
        Prefeeding635.0 (27.0)21.0–121.00.38
        Postfeeding541.0 (16.0)20.6–175.40.47
    Peak
        Prefeeding564.0 (5.0)27.4–135.70.22
        Postfeeding5103.0 (31.0)31.6–112.90.23
Day 30.037
    Trough
        Prefeeding854.0 (32.0)38.1–136.30.43
        Postfeeding862.5 (48.5)42.1–169.50.48
    Peak
        Prefeeding8106.0 (81.0)45.1–193.30.23
        Postfeeding6126.5 (53.0)52.3–182.80.35
Day 40.075
    Trough
        Prefeeding874.0 (27.0)54.7–158.20.41
        Postfeeding870.5 (32.5)49.4–210.00.35
    Peak
        Prefeeding8161.0 (70.0)80.0–281.40.33
        Postfeeding8199.0 (99.5)109.2–239.50.48
Day 140.125
    Trough
        Prefeeding8121.0 (136.0)60.5–257.90.42
        Postfeeding8119.0 (182.0)66.7–335.60.56
    Peak
        Prefeeding8201.0 (75.5)105.2–367.10.53
        Postfeeding8231.0 (114.5)61.9–462.00.54
Day 300.152
    Trough
        Prefeeding892.0 (84.5)32.8–222.70.38
        Postfeeding8125.5 (217.0)67.9–449.50.44
    Peak
        Prefeeding8194.0 (81.0)83.4–407.10.49
        Postfeeding8220.5 (158.5)159.2–359.50.55