TABLE 2

Methadone Concentrations in Maternal Plasma According to Group

Sampling PeriodBreastfeedingControlP
nMethadone Concentration, Median (Interquartile Range), ng/mLnMethadone Concentration, Median (Interquartile Range), ng/mL
Day 1
    Trough8122.0 (119.0)897.5 (110.5)NS
    Peak8228.5 (134.0)8271.5 (89.5)NS
Day 2
    Trough8113.0 (115.0)8107.5 (123.0)NS
    Peak6345.5 (255.0)7324.0 (212.0)NS
Day 3
    Trough8147.5 (99.0)7124.0 (159.0)NS
    Peak8306.5 (174.5)8299.5 (176.0)NS
Day 4
    Trough8194.0 (86.5)6148.0 (79.0)NS
    Peak8386.5 (223.5)7359.0 (100.0)NS
Day 14
    Trough8279.0 (206.5)8337.5 (300.0)NS
    Peak8500.0 (244.5)8477.0 (266.5)NS
Day 30
    Trough8320.5 (231.5)8254.0 (220.5)NS
    Peak8506.0 (368.5)8439.0 (277.5)NS