TABLE 2

Cardiac Catheterization and Pulmonary Vascular Reactivity Data for 13 Patients With BPD and PAH

PatientConditionCardiac Index, L/min per m2Aortic Pressure, mm HgRV Pressure, mm HgMean PA Pressure, mm HgPCW Pressure, mm HgPVR Index, WUsPVR/SVR Ratio
1RA3.011290696210.74
100% O22.61256036611.50.30
NO2.61255332510.40.27
Change from RA to 100% O2, %−12+12−33−480−45−59
Change from RA to NO, %−13+12−41−54−17−50−64
2100% O24.080110581211.50.96
NO2.6755642912.70.60
Change from 100% O2 to NO, %−35−6−49−28−2510−37
3aRA3.28082591512.90.83
100% O23.5836040113.90.24
NO4.5856535162.00.16
Change from RA to 100% O2, %94−27−32−27−70−71
Change from RA to NO, %416−21−417−84−81
4RA3.39010046512.40.72
100% O24.112012564314.90.80
NO3.676673438.60.52
Change from RA to 100% O2, %24332539−402012
Change from RA to NO, %9−16−33−26−40−31−28
5aRA2.1855030117.10.24
NO2.5895431124.10.17
Change from RA to NO, %195839−42−31
6RA3.2805538138.60.66
100% O25.8977350156.60.45
NO4.71107050147.60.48
Change from RA to 100% O2, %8121333215−23−32
Change from RA to NO, %473827328−11−27
7RA3.898503868.40.43
100% O24.190543877.60.49
NO3.8105493467.40.41
Change from RA to 100% O2, %8−88017−1014
Change from RA to NO, %07−2−110−12−4
8RA2.7945035118.90.32
100% O22.61005035138.50.32
NO2.5924532118.40.30
Change from RA to 100% O2, %−460018−4−3
Change from RA to NO, %−7−2−10−90−5−7
9RA2.48560421113.00.47
100% O22.3925438169.50.34
NO2.5895034148.00.30
Change from RA to 100% O2, %−48−10−1045−26−28
Change from RA to NO, %45−17−1927−38−35
10aRA4.4766745116.10.57
100% O26.4826542162.00.23
NO6.0916840162.30.22
Change from RA to 100% O2, %458−3−745−67−60
Change from RA to NO, %36201−1145−62−61
11RA2.811076501014.30.58
100% O22.81175537119.30.29
NO2.71104629126.30.22
Change from RA to 100% O2, %06−28−2610−35−50
Change from RA to NO, %−40−39−4220−56−61
12RA3.41006035117.10.35
100% O24.1964224103.40.20
NO3.8863522103.20.20
Change from RA to 100% O2, %21−4−30−31−9−52−44
Change from RA to NO, %12−14−42−37−9−55−44
13RA3.29070491510.60.40
100% O23.17561441310.00.78
NO3.4696038166.50.60
Change from RA to 100% O2, %−3−17−13−10−13−694
Change from RA to NO, %6−23−14−22−7−3949
All, mean ± SDRA3.2 ± 0.790 ± 1066 ± 1643 ± 810.8 ± 3.19.9 ± 2.80.51 ± 0.18
100% O23.9 ± 1.394 ± 1468 ± 2543 ± 1111.5 ± 3.97.9 ± 3.80.45 ± 0.26
NO3.6 ± 1.190 ± 1355 ± 1135 ± 711.6 ± 4.16.4 ± 3.10.34 ± 0.16
Change from RA to 100% O2, %15 ± 286 ± 13−6 ± 21−8 ± 265 ± 26−29 ± 28b−21 ± 48
Change from RA to NO, %11 ± 232 ± 16−16 ± 23b−18 ± 21b4 ± 22−35 ± 27c−33 ± 33b
  • PCW indicates pulmonary capillary wedge; SVR, systemic vascular resistance; RA, room air.

  • a These 3 patients had atrial septal defects, with pulmonary/systemic blood flow ratios of 1.1 to 1.3 at baseline, which increased to 1.7 to 2.1 with oxygen and NO.

  • b P ≤ .01, compared with baseline.

  • c P ≤ .001, compared with baseline.