TABLE 1

Demographic and Diagnostic Characteristics of 42 Premature Infants With BPD and PAH

VariableAll Patients (n = 42)Severe PAH (n = 18)aLess-Than-Severe PAH (n = 24)
Gestational age at birth, median (range), wk26 (23–31)25.5 (23–31)26.5 (23–32)
Birth weight, median (range), g702 (355–1320)702 (525–955)696 (355–1320)
Weight of <3rd percentile for age, n (%)11 (26)8 (44)3 (13)
Male, n (%)21 (50)11 (61)10 (42)
BPD severity, n (%)b
    Severe16 (41)8 (47)8 (36)
    Moderate22 (56)8 (47)14 (64)
    Mild1 (3)1 (6)0 (0)
Mechanical ventilation for >2 mo, n (%)12 (29)7 (39)5 (21)
Ever supported with high-frequency ventilation, n (%)22 (52)13 (72)9 (38)
Tracheostomy, n (%)6 (14)5 (25)1 (4)
Patent ductus arteriosus treated with indomethacin or surgery, n (%)26 (63)10 (56)16 (67)
Grade III or IV intraventricular hemorrhage, n (%)5 (12)1 (6)4 (17)
Necrotizing enterocolitis, n (%)10 (24)2 (11)8 (33)
Twin-gestation pregnancy, n (%)6 (14)1 (6)5 (21)
Atrial septal defect, n (%)3 (7)2 (11)1 (4)
Trisomy 21, n (%)2 (5)2 (11)0 (0)
Born at affiliated delivery hospital covered by Children's Hospital cardiology service, n (%)16 (38)4 (22)12 (50)
Diagnosed with PAH after discharge from initial postnatal hospitalization, n (%)26 (62)11 (61)15 (63)
  • a Systemic or suprasystemic RV pressure was documented at some point during the study period.

  • b BPD severity, graded according to the recommendations of the National Heart, Lung, and Blood Institute workshop,2 could not be differentiated between moderate and severe for 3 patients (1 with severe PAH and 2 with less-than-severe PAH) who required supplemental oxygen at gestational age of 36 weeks but for whom the fraction of inspired oxygen at that time could not be determined from available records.