Recommended Trivalent Seasonal Influenza Vaccines for Different Age Groups: United States, 2012–2013 Influenza Season

VaccineTrade NameManufacturerPresentationOvalbumin Content (microgram of ovalbumin/0.5-mL dose)Thimerosal Mercury Content (microgram of Hg/0.5-mL dose)Age Group
TIVFluzoneSanofi Pasteur0.25-mL prefilled syringe∼0.1a06–35 mo
0.5-mL prefilled syringe∼0.1a0≥36 mo
0.5-mL vial∼0.1a0≥36 mo
5.0-mL multidose vial∼0.1a25≥6 mo
TIVFluzone IDSanofi Pasteur0.1-mL prefilled microinjection∼0.02/0.1 mL dosea018–64 y
TIVFluzone high doseSanofi Pasteur0.5-mL prefilled syringe∼0.1a0≥65 y
TIVFluvirinNovartis0.5-mL prefilled syringe≤1b≤1.0≥4 y
5.0-mL multidose vial≤1b25≥4 y
TIVAgrifluNovartis0.5-mL prefilled syringe<0.4b0≥18 y
TIVFluarixGlaxoSmithKline0.5-mL prefilled syringe≤0.05b0≥3 y
TIVFluLavalID Biomedical Corporation of Quebec (distributed by GlaxoSmithKline)5.0-mL multidose vial≤1b25≥18 y
TIVAfluriaCSL Biotherapies (distributed by Merck)0.5-mL prefilled syringe≤1b0≥9 yc
5-mL multidose vial24.5≥9 yc
LAIVFluMistMedImmune0.2-mL sprayer<0.2402–49 y
  • Data sources: American Academy of Pediatrics, Committee on Infectious Diseases. Recommendations for prevention and control of influenza in children, 2011-2012. Pediatrics. 2011;128(4):818; and Centers for Disease Control and Prevention (CDC). Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2011. MMWR Morb Mortal Wkly Rep. 2011;60(33):1130.

  • a Personal communication with Sanofi Pasteur. 2011.

  • b Package inserts.

  • c Age indication per package insert is ≥5 years; however, the ACIP recommends Afluria not be used in children aged 6 months through 8 years because of increased reports of febrile reactions noted in this age group. If no other age-appropriate, licensed inactivated seasonal influenza vaccine is available for a child 5 through 8 years of age who has a medical condition that increases the child’s risk of influenza complications, Afluria can be used; however, pediatricians should discuss with the parents or caregivers the benefits and risks of influenza vaccination with Afluria before administering this vaccine.