TABLE 1

Domains Used to Assess Strength of Evidence

DomainDescription
Risk of biasReflects issues in study design and conduct that could result in biased estimates of effect
ConsistencyReflects similarity of effect sizes seen across studies. Consistency cannot be assessed when only 1 study is available
DirectnessReflects the relationship between the intervention and the ultimate health outcome of interest
PrecisionReflects the level of certainty around the effect observed