Treatment With Antidepressant Medication: Warning Signs for Family Members to Contact the Physician

New or more frequent thoughts of wanting to die
Self-destructive behavior
Signs of increased anxiety/panic, agitation, aggressiveness, impulsivity, insomnia, or irritability
New or more involuntary restlessness (akathesia), such as pacing or fidgeting
Extreme degree of elation or energy
Fast, driven speech
New onset of unrealistic plans or goals
  • (Reprinted with permission from the Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Association; 2000.)