RT Journal Article
SR Electronic
T1 Ranitidine-Induced Delirium in a 7-Year-Old Girl: A Case Report
JF Pediatrics
JO Pediatrics
FD American Academy of Pediatrics
SP e20182428
DO 10.1542/peds.2018-2428
VO 143
IS 2
A1 Castro, Roberta Esteves Vieira de
A1 Sousa, Carolina da Cunha
A1 de Magalhães-Barbosa, Maria Clara
A1 Prata-Barbosa, Arnaldo
A1 Cheniaux, Elie
YR 2019
UL http://pediatrics.aappublications.org/content/143/2/e20182428.abstract
AB Ranitidine is a histamine-2 blocker commonly prescribed in PICUs for the prophylaxis of gastrointestinal bleeding and stress ulcers. However, it can be associated to central nervous system side effects, such as delirium, in adults. We present the first case of a child presenting delirium possibly caused by anticholinergic toxidrome secondary to the use of ranitidine, resolving after drug discontinuation. With this case report, we reinforce that a wide variety of clinical conditions can trigger delirium and that the best therapeutic approach is to minimize risk factors.