PT  - JOURNAL ARTICLE
AU  - Dixon, Brian E.
AU  - Zimet, Gregory D.
AU  - Xiao, Shan
AU  - Tu, Wanzhu
AU  - Lindsay, Brianna
AU  - Church, Abby
AU  - Downs, Stephen M.
TI  - An Educational Intervention to Improve HPV Vaccination: A Cluster Randomized Trial
AID  - 10.1542/peds.2018-1457
DP  - 2019 Jan 01
TA  - Pediatrics
PG  - e20181457
VI  - 143
IP  - 1
4099  - http://pediatrics.aappublications.org/content/143/1/e20181457.short
4100  - http://pediatrics.aappublications.org/content/143/1/e20181457.full
SO  - Pediatrics2019 Jan 01; 143
AB  - Video AbstractBACKGROUND: Human papillomavirus (HPV) infection can lead to serious health issues and remains the most common sexually transmitted infection. Despite availability of effective vaccines, HPV vaccination rates are suboptimal.METHODS: In a cluster randomized trial, an intervention used to target parents of adolescents (11–17 years) eligible for a dose of HPV vaccine, was tested in pediatric clinics part of an urban health system. Parents watched a digital video outlining the risks and benefits of vaccine using a tablet in the examination room. The primary outcome was change in HPV vaccine status 2 weeks after the clinic visit. An intention-to-treat analysis for the primary outcome used generalized estimating equations to accommodate the potential cluster effect of clinics.RESULTS: A total of 1596 eligible adolescents were observed during the 7-month trial. One-third of adolescents visited an intervention clinic. Adolescents who attended an intervention clinic were more likely to be younger (11–12 years) than those who attended a control clinic (72.4% vs 49.8%; P < .001). No differences in race or sex were observed. The proportion of adolescents with an observed change in vaccine status was higher for those attending an intervention clinic (64.8%) versus control clinic (50.1%; odds ratio, 1.82; 95% confidence interval, 1.47–2.25; P < .001). Adolescents whose parents watched the video had a 3-times greater odds of receiving a dose of the HPV vaccine (78.0%; odds ratio, 3.07; 95% confidence interval, 1.47–6.42; P = .003).CONCLUSIONS: Educational interventions delivered within a clinical setting hold promise to improve vaccination behaviors.