PT  - JOURNAL ARTICLE
AU  - Jegatheesan, Priya
AU  - Song, Dongli
AU  - Angell, Cathy
AU  - Devarajan, Kamakshi
AU  - Govindaswami, Balaji
TI  - Oxygen Saturation Nomogram in Newborns Screened for Critical Congenital Heart Disease
AID  - 10.1542/peds.2012-3320
DP  - 2013 Jun 01
TA  - Pediatrics
PG  - e1803--e1810
VI  - 131
IP  - 6
4099  - http://pediatrics.aappublications.org/content/131/6/e1803.short
4100  - http://pediatrics.aappublications.org/content/131/6/e1803.full
SO  - Pediatrics2013 Jun 01; 131
AB  - OBJECTIVE: To establish simultaneous pre- and postductal oxygen saturation nomograms in asymptomatic newborns when screening for critical congenital heart disease (CCHD) at ∼24 hours after birth.METHODS: Asymptomatic term and late preterm newborns admitted to the newborn nursery were screened with simultaneous pre- and postductal oxygen saturation measurements at ∼24 hours after birth. The screening program was implemented in a stepwise fashion in 3 different affiliated institutions. Data were collected prospectively from July 2009 to March 2012 in all 3 centers.RESULTS: We screened 13 714 healthy newborns at a median age of 25 hours. The mean preductal saturation was 98.29% (95% confidence interval [CI]: 98.27–98.31), median 98%, and mean postductal saturation was 98.57% (95% CI: 98.55–98.60), median 99%. The mean difference between the pre- and postductal saturation was −0.29% (95% CI: −0.31 to −0.27) with P < .00005. Its clinical relevance to CCHD screening remains to be determined. The postductal saturation was equal to preductal saturation in 38% and greater than preductal saturation in 40% of the screens.CONCLUSIONS: We have established simultaneous pre- and postductal oxygen saturation nomograms at ∼24 hours after birth based on >13 000 asymptomatic newborns. Such nomograms are important to optimize screening thresholds and methodology for detecting CCHD.Abbreviations:CCHD — critical congenital heart diseaseCI — confidence interval