RT Journal Article
SR Electronic
T1 Multicentric Castleman Disease in an HHV8-Infected Child Born to Consanguineous Parents With Systematic Review
JF Pediatrics
JO Pediatrics
FD American Academy of Pediatrics
SP e199
OP e203
DO 10.1542/peds.2010-2739
VO 129
IS 1
A1 Leroy, Sandrine
A1 Moshous, Despina
A1 Cassar, Olivier
A1 Reguerre, Yves
A1 Byun, Minji
A1 Pedergnana, Vincent
A1 Canioni, Danielle
A1 Gessain, Antoine
A1 Oksenhendler, Eric
A1 Fieschi, Claire
A1 Mahlaoui, Nizar
A1 Rivière, Jean-Pierre
A1 Herbigneaux, Rose-Marie
A1 Muszlak, Matthias
A1 Arnaud, Jean-Pierre
A1 Fischer, Alain
A1 Picard, Capucine
A1 Blanche, Stéphane
A1 Plancoulaine, Sabine
A1 Casanova, Jean-Laurent
YR 2012
UL http://pediatrics.aappublications.org/content/129/1/e199.abstract
AB Childhood multicentric Castleman disease (MCD) is a rare and unexplained lymphoproliferative disorder. We report a human herpesvirus-8 (HHV-8)-infected child, born to consanguineous Comorian parents, who displayed isolated MCD in the absence of any known immunodeficiency. We also systematically review the clinical features of the 32 children previously reported with isolated and unexplained MCD. The characteristics of this patient and the geographic areas of origin of most previous cases suggest that pediatric MCD is associated with HHV-8 infection. Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection.Abbreviations:CD — Castleman diseaseHHV-8 — human herpes virus 8Ig — immunoglobulinKS — Kaposi sarcomaMCD — multicentric Castleman diseasePCR — polymerase chain reactionSNP — single-nucleotide polymorphism