PT  - JOURNAL ARTICLE
AU  - Leroy, Sandrine
AU  - Moshous, Despina
AU  - Cassar, Olivier
AU  - Reguerre, Yves
AU  - Byun, Minji
AU  - Pedergnana, Vincent
AU  - Canioni, Danielle
AU  - Gessain, Antoine
AU  - Oksenhendler, Eric
AU  - Fieschi, Claire
AU  - Mahlaoui, Nizar
AU  - Rivière, Jean-Pierre
AU  - Herbigneaux, Rose-Marie
AU  - Muszlak, Matthias
AU  - Arnaud, Jean-Pierre
AU  - Fischer, Alain
AU  - Picard, Capucine
AU  - Blanche, Stéphane
AU  - Plancoulaine, Sabine
AU  - Casanova, Jean-Laurent
TI  - Multicentric Castleman Disease in an HHV8-Infected Child Born to Consanguineous Parents With Systematic Review
AID  - 10.1542/peds.2010-2739
DP  - 2012 Jan 01
TA  - Pediatrics
PG  - e199--e203
VI  - 129
IP  - 1
4099  - http://pediatrics.aappublications.org/content/129/1/e199.short
4100  - http://pediatrics.aappublications.org/content/129/1/e199.full
SO  - Pediatrics2012 Jan 01; 129
AB  - Childhood multicentric Castleman disease (MCD) is a rare and unexplained lymphoproliferative disorder. We report a human herpesvirus-8 (HHV-8)-infected child, born to consanguineous Comorian parents, who displayed isolated MCD in the absence of any known immunodeficiency. We also systematically review the clinical features of the 32 children previously reported with isolated and unexplained MCD. The characteristics of this patient and the geographic areas of origin of most previous cases suggest that pediatric MCD is associated with HHV-8 infection. Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection.Abbreviations:CD — Castleman diseaseHHV-8 — human herpes virus 8Ig — immunoglobulinKS — Kaposi sarcomaMCD — multicentric Castleman diseasePCR — polymerase chain reactionSNP — single-nucleotide polymorphism