RT Journal Article
SR Electronic
T1 Antenatal Corticosteroids Appear to Reduce the Risk of Postnatal Germinal Matrix Hemorrhage in Intubated Low Birth Weight Newborns
JF Pediatrics
JO Pediatrics
FD American Academy of Pediatrics
SP 1083
OP 1088
VO 91
IS 6
A1 Leviton, Alan
A1 Kuban, Karl C.
A1 Van Marter, Linda
A1 Pagano, Marcello
A1 Allred, Elizabeth N.
YR 1993
UL http://pediatrics.aappublications.org/content/91/6/1083.abstract
AB Objective. To determine to what extent the reduced risk in preterm newborns of intracranial hemorrhage attributed to antenatal corticosteroids (ANCS) reflects reductions in the incidence of respiratory distress and its correlates. Methods. In a sample of 239 very low birth weight newborns recruited for a clinical trial of phenobarbital prophylaxis of subependymal/intraventricular hemorrhage, we explored the relationship between ANCS, the occurrence of germinal matrix hemorrhage (GMH) that first became evident after the 12th postnatal hour, and putative intervening variables such as acidosis, elevated peak inspiratory pressure, pneumothorax-pulmonary interstitial emphysema, and elevated continuous positive airway pressure. Results. In multivariate models adjusting for confounders, newborns exposed to ANCS were at approximately one third the risk of GMH experienced by newborns not exposed to a full course of ANCS. The additions of measures and correlates of respiratory distress severity to these models did not change the GMH risk associated with ANCS. Conclusion. The GMH-protective effect of ANCS does not appear to be a consequence of enhanced pulmonary maturation.