RT Journal Article SR Electronic T1 Letter to the Editor JF Pediatrics JO Pediatrics FD American Academy of Pediatrics SP 490 OP 491 VO 86 IS 3 A1 Halsey, Neal A1 Holt, Elizabeth YR 1990 UL http://pediatrics.aappublications.org/content/86/3/490.2.abstract AB Dr Brunskill's primary point appears to be in the final sentence of his letter. As noted in our discussion, we are well aware of the potential for hidden confounding factors in retrospective observational studies... We attempted to minimize this possibility by obtaining information on an extensive list of factors that might have confounded the relationship between vaccination and mortality and by controlling for these factors through multivariate analysis.1 Despite our rigor, we could have failed to measure all possible confounding variables.