PT  - JOURNAL ARTICLE
AU  - Harris, Robert L.
TI  - Rapidly Administered Hypertonic Solutions
DP  - 1971 Jan 01
TA  - Pediatrics
PG  - 154--154
VI  - 47
IP  - 1
4099  - http://pediatrics.aappublications.org/content/47/1/154.1.short
4100  - http://pediatrics.aappublications.org/content/47/1/154.1.full
SO  - Pediatrics1971 Jan 01; 47
AB  - The article "Clinically Significant Physiological Changes from Rapidly Administered Hypertonic Solutions: Acute Osmol Poisoning" (Pediatrics, 46:267, 1970) by Kravath, et al. is a valuable addition to the pediatric literature. In a series of interesting experiments the authors again document the potential dangers of rapid intravenous infusions of hypertonic solutions. However, the implication that the experiments so performed are necessarily applicable inthe human organism need some clarification. In considering the effects of an intravenous infusion in the human, three factors should be considered: (1) osmoiality, (2) volume, and (3) total dose.