RT Journal Article
SR Electronic
T1 RESULTS OF TREATMENT AND TERMINATION OF THE DIET IN PHENYLKETONURIA (PKU)
JF Pediatrics
JO Pediatrics
FD American Academy of Pediatrics
SP 881
OP 890
VO 46
IS 6
A1 Kang, Ellen Song
A1 Sollee, Natalie D.
A1 Gerald, Park S.
YR 1970
UL http://pediatrics.aappublications.org/content/46/6/881.abstract
AB The mean I.Q. of 27 PKU patients at the mean age of 3 years 10 months treated before 3 weeks of age was comparable to that of their unaffected siblings. The mean I.Q., of 12 patients at the mean age of 5 years 6 months treated between 3 and 6 weeks of age fell significantly below the mean I.Q. of their unaffected siblings. Seventeen patients treated after 8 months of age did not differ in their mean I.Q. at the end of treatment from 11 untreated patients, despite the observation that more than half of the late-treated patients achieved significant gains during the course of their treatment. Patients off dietary therapy did not appear to deteriorate over a follow-up duration of 2 to 3½ years. Eleven were followed for 6 years without evidence of deterioration. Thirteen atypical PKU's showed normal intellectual development. An unexplained predominance of males was observed in our group of atypical PKU patients.