PT  - JOURNAL ARTICLE
AU  - Kang, Ellen Song
AU  - Sollee, Natalie D.
AU  - Gerald, Park S.
TI  - RESULTS OF TREATMENT AND TERMINATION OF THE DIET IN PHENYLKETONURIA (PKU)
DP  - 1970 Dec 01
TA  - Pediatrics
PG  - 881--890
VI  - 46
IP  - 6
4099  - http://pediatrics.aappublications.org/content/46/6/881.short
4100  - http://pediatrics.aappublications.org/content/46/6/881.full
SO  - Pediatrics1970 Dec 01; 46
AB  - The mean I.Q. of 27 PKU patients at the mean age of 3 years 10 months treated before 3 weeks of age was comparable to that of their unaffected siblings. The mean I.Q., of 12 patients at the mean age of 5 years 6 months treated between 3 and 6 weeks of age fell significantly below the mean I.Q. of their unaffected siblings. Seventeen patients treated after 8 months of age did not differ in their mean I.Q. at the end of treatment from 11 untreated patients, despite the observation that more than half of the late-treated patients achieved significant gains during the course of their treatment. Patients off dietary therapy did not appear to deteriorate over a follow-up duration of 2 to 3½ years. Eleven were followed for 6 years without evidence of deterioration. Thirteen atypical PKU's showed normal intellectual development. An unexplained predominance of males was observed in our group of atypical PKU patients.