RT Journal Article
SR Electronic
T1 Impact of Rotavirus Vaccination on Hospital-Acquired Rotavirus Gastroenteritis in Children
JF Pediatrics
JO Pediatrics
FD American Academy of Pediatrics
SP e264
OP e270
DO 10.1542/peds.2010-1830
VO 127
IS 2
A1 Anderson, Evan J.
A1 Rupp, Angela
A1 Shulman, Stanford T.
A1 Wang, Deli
A1 Zheng, Xiaotian
A1 Noskin, Gary A.
YR 2011
UL http://pediatrics.aappublications.org/content/127/2/e264.abstract
AB OBJECTIVE: Data show that after the implementation of routine rotavirus vaccination for infants in the United States, community-acquired (CA) rotavirus cases declined substantially in the 2007–2008 season. The impact of community-based rotavirus vaccination on the substantial burden of hospital-acquired (HA) rotavirus has not been documented.PATIENTS AND METHODS: We assessed CA and HA rotavirus, respiratory syncytial virus, and influenza infections at Children's Memorial Hospital for 5 winter seasons (defined as occurring from September through May) from 2003 to 2008. We also report rotavirus data from the 2008–2009 season.RESULTS: A similar dramatic decline (&gt;60% compared with the median of previous seasons) occurred in the rates of cases of both CA (P &lt; .0001) rotavirus hospitalizations and HA (P &lt; .01) rotavirus infections in the 2007–2008 season compared with previous seasons, whereas the rates of CA and HA influenza and respiratory syncytial virus, respectively, remained stable. Improvements in hand-hygiene compliance did not correlate with a reduction in the transmission rate of rotavirus in the hospital. Both CA and HA rotavirus rates remained much lower in the 2008–2009 than in the 2003–2007 seasons.CONCLUSIONS: Community-based rotavirus vaccination is associated with a substantial reduction in the number of children who are admitted with rotavirus. These data also indicate that routine community-based rotavirus infant vaccination protects hospitalized children from acquiring rotavirus. Vaccination efforts should be encouraged as a strategy to affect the substantial burden of HA rotavirus.