PT  - JOURNAL ARTICLE
AU  - Kilic, Sara Sebnem
AU  - Kilicbay, Fatih
TI  - Interferon-α Treatment of Molluscum Contagiosum in a Patient With Hyperimmunoglobulin E Syndrome
AID  - 10.1542/peds.2005-2706
DP  - 2006 Jun 01
TA  - Pediatrics
PG  - e1253--1255
VI  - 117
IP  - 6
4099  - http://pediatrics.aappublications.org/content/117/6/e1253.short
4100  - http://pediatrics.aappublications.org/content/117/6/e1253.full
SO  - Pediatrics2006 Jun 01; 117
AB  - We report widely disseminated molluscum contagiosum that occurred in a 9-year-old boy secondary to hyperimmunoglobulin E syndrome, a primary immunodeficiency disorder. Cutaneous examination revealed numerous, widespread, skin-colored to translucent, firm, umbilicated papules of varying sizes. They were distributed throughout the perineal and gluteal areas and bilaterally over his lower limbs. A biopsy specimen from his skin lesion demonstrated lobulated epidermal growth that consisted of keratinocytes with large intracytoplasmic eosinophilic inclusion bodies and a central crater. These findings were consistent with the diagnosis of molluscum contagiosum. Many treatments for his skin lesions were ineffective, including physical destruction or manual extrusion of the lesions; cryotherapy; curettage; and topical therapies with phenol, trichloroacetic acid, and imiquimod. The patient was treated successfully with subcutaneous interferon-α for 6 months without any adverse effect.