PT  - JOURNAL ARTICLE
AU  - Galassi, Claudia
AU  - De Sario, Manuela
AU  - Biggeri, Annibale
AU  - Bisanti, Luigi
AU  - Chellini, Elisabetta
AU  - Ciccone, Giovannino
AU  - Petronio, Maria Grazia
AU  - Piffer, Silvano
AU  - Sestini, Piersante
AU  - Rusconi, Franca
AU  - Viegi, Giovanni
AU  - Forastiere, Francesco
TI  - Changes in Prevalence of Asthma and Allergies Among Children and Adolescents in Italy: 1994–2002
AID  - 10.1542/peds.2004-2709
DP  - 2006 Jan 01
TA  - Pediatrics
PG  - 34--42
VI  - 117
IP  - 1
4099  - http://pediatrics.aappublications.org/content/117/1/34.short
4100  - http://pediatrics.aappublications.org/content/117/1/34.full
SO  - Pediatrics2006 Jan 01; 117
AB  - BACKGROUND. Several studies conducted during the 1990s indicated an increase in the prevalence of symptoms of asthma; more recent investigations suggest that the trend is stabilizing or may even be reversing.OBJECTIVE. We compared 2 cross-sectional surveys conducted in 1994 and 2002 in 8 areas in northern and central Italy, to evaluate prevalence changes for asthma, allergic rhinitis, and eczema.METHODS. The International Study of Asthma and Allergies in Childhood methods and questionnaires were used to investigate 6- to 7-year-old children (16115 and 11287 questionnaires completed by parents in 1994–1995 and 2002, respectively) and 13- to 14-year-old adolescents (19723 and 10267 questionnaires completed by adolescents in 1994–1995 and 2002, respectively). In each phase, the overall response rate was >90%. Prevalence changes were calculated as the absolute difference between the prevalence recorded on the 2 occasions.RESULTS. The prevalence of wheeze (past 12 months) increased slightly among children (change: 0.8%; 95% confidence interval [CI]: 0.0% to 1.6%) and was rather stable among adolescents. Symptoms of allergic rhinitis (children: change: 5.2%; 95% CI: 4.0% to 6.4%; adolescents: change: 4.1%; 95% CI: 1.9% to 6.3%) and symptoms of atopic eczema (children: change: 4.4%; 95% CI: 3.6% to 5.2%; adolescents: change: 2.1%; 95% CI: 1.2% to 3.0%) increased clearly in both age groups. There was some heterogeneity across the centers among adolescents, especially for allergic rhinitis, with larger increases seen in the 3 metropolitan areas. The changes observed paralleled profound family changes, ie, better parental education, higher rates of maternal employment, and lower rates of exposure to parental smoke. These factors, however, do not explain all of the observed changes in prevalence.CONCLUSIONS. The results indicate that the epidemiologic features of asthma and allergies in Italy are changing rapidly, although the causes are still uncertain.