PT  - JOURNAL ARTICLE
AU  - Roy, Sumita
AU  - Kaplan, Edward L.
AU  - Rodriguez, Benigno
AU  - Schreiber, John R.
AU  - Salata, Robert A.
AU  - Palavecino, Elizabeth
AU  - John, Chandy C.
TI  - A Family Cluster of Five Cases of Group A Streptococcal Pneumonia
AID  - 10.1542/peds.112.1.e61
DP  - 2003 Jul 01
TA  - Pediatrics
PG  - e61--e65
VI  - 112
IP  - 1
4099  - http://pediatrics.aappublications.org/content/112/1/e61.short
4100  - http://pediatrics.aappublications.org/content/112/1/e61.full
SO  - Pediatrics2003 Jul 01; 112
AB  - A cluster of 5 family members, a mother and 4 children, were hospitalized for severe group A Streptococcus (GAS) pneumonia. Three family members had complications: sepsis (1), empyema (2), and a sterile parapneumonic effusion (1). Two additional family members had symptoms of upper respiratory tract infection, and 1 was hospitalized for these symptoms. GAS was isolated from the blood of 1 patient, the pleural fluid of 2 patients, and the oropharynx of 6 patients. Pulsed field gel electrophoresis testing revealed an identical deoxyribonucleic acid pattern in all 7 isolates. Genotyping revealed the speA gene and serotyping the T-1, M-1 serotype in all isolates. This family cluster of invasive GAS disease is the largest reported to date, with an attack rate of 41.7% (5 of 12 family members). This report provides further support for antibiotic prophylaxis of close contacts of individuals with invasive GAS disease.