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American Academy of Pediatrics
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Diarrhea in Preschool Children and Lactobacillus reuteri: A Randomized Controlled Trial

Pedro Gutierrez-Castrellon, Gabriel Lopez-Velazquez, Luisa Diaz-Garcia, Carlos Jimenez-Gutierrez, Javier Mancilla-Ramirez, Juliana Estevez-Jimenez and Minerva Parra
Pediatrics March 2014, peds.2013-0652; DOI: https://doi.org/10.1542/peds.2013-0652
Pedro Gutierrez-Castrellon
aNational Perinatology Institute, Mexico City, Mexico
bHospital General Dr Manuel Gea González, Tlalpan, Mexico,
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Gabriel Lopez-Velazquez
cNational Pediatric Institute, Mexico City, Mexico
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Luisa Diaz-Garcia
cNational Pediatric Institute, Mexico City, Mexico
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Carlos Jimenez-Gutierrez
aNational Perinatology Institute, Mexico City, Mexico
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Javier Mancilla-Ramirez
aNational Perinatology Institute, Mexico City, Mexico
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Juliana Estevez-Jimenez
aNational Perinatology Institute, Mexico City, Mexico
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Minerva Parra
cNational Pediatric Institute, Mexico City, Mexico
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Abstract

OBJECTIVES To evaluate whether daily administration of Lactobacillus reuteri DSM 17938 reduces the frequency and duration of diarrheal episodes and other health outcomes in day school children in Mexico.

METHODS: Healthy children (born at term, aged 6–36 months) attending day care centers were enrolled in this randomized, double-blind, placebo-controlled trial. They received L reuteri DSM 17938 (dose 108 colony-forming unit; n = 168) or identical placebo (n = 168) by mouth, daily for 3 months, after which they were followed-up after a further 3 months without supplementation.

RESULTS: Data from all children were included in the final analysis. L reuteri DSM 17938 significantly reduced the frequency and duration of episodes of diarrhea and respiratory tract infection at both 3 and 6 months (P < .05). Additionally, the number of doctor visits, antibiotic use, absenteeism from day school and parental absenteeism from work were significantly reduced in the L reuteri group (P < .05). A cost-benefit analysis revealed significant reductions in costs in the L reuteri-treated children. No adverse events related to the study product were reported.

CONCLUSIONS: In healthy children attending day care centers, daily administration of L reuteri DSM 17938 had a significant effect in reducing episodes and duration of diarrhea and respiratory tract infection, with consequent cost savings for the community.

  • Lactobacillus reuteri DSM 17938
  • diarrhea
  • children
  • Accepted January 13, 2014.
  • Copyright © 2014 by the American Academy of Pediatrics

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Pediatrics
Vol. 147, Issue 1
1 Jan 2021
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Diarrhea in Preschool Children and Lactobacillus reuteri: A Randomized Controlled Trial
Pedro Gutierrez-Castrellon, Gabriel Lopez-Velazquez, Luisa Diaz-Garcia, Carlos Jimenez-Gutierrez, Javier Mancilla-Ramirez, Juliana Estevez-Jimenez, Minerva Parra
Pediatrics Mar 2014, peds.2013-0652; DOI: 10.1542/peds.2013-0652

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Diarrhea in Preschool Children and Lactobacillus reuteri: A Randomized Controlled Trial
Pedro Gutierrez-Castrellon, Gabriel Lopez-Velazquez, Luisa Diaz-Garcia, Carlos Jimenez-Gutierrez, Javier Mancilla-Ramirez, Juliana Estevez-Jimenez, Minerva Parra
Pediatrics Mar 2014, peds.2013-0652; DOI: 10.1542/peds.2013-0652
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