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American Academy of Pediatrics
EXPERIENCE AND REASON

Central Pontine Myelinolysis in a Previously Healthy 4-Year-Old Child With Acute Rotavirus Gastroenteritis

Laura Gregorio, Curtis L. Sutton and Deborah A. Lee
Pediatrics May 1997, 99 (5) 738-742; DOI: https://doi.org/10.1542/peds.99.5.738
Laura Gregorio
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Curtis L. Sutton
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Deborah A. Lee
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Acute gastroenteritis is one of the most common childhood illnesses encountered today. Vomiting and diarrhea often cause dehydration. Although the disease is usually self-limiting, patients may require rehydration therapy.1-2

Central pontine myelinolysis (CPM) is rare, with fewer than 30 cases reported in children. First described in 1959,3 it is a demyelinating process that affects the central pons and may involve other white matter areas. CPM presents with an altered level of consciousness followed by spastic quadriparesis and pseudobulbar palsy.4 It is most often described as a complication of rapid sodium shifts in patients with underlying disease, frequently involving the liver.

We present the first case of CPM documented by magnetic resonance imaging (MRI) in a previously healthy young child after rehydration for rotavirus gastroenteritis.

CASE REPORT

A 4½-year-old previously healthy and developmentally normal right-handed boy presented to the emergency department of an outlying community hospital with a 3-day history of watery diarrhea and vomiting. He had no prior history of unusual gastrointestinal illnesses. According to his mother, he had been cooperative and able to follow complex commands. He had been given several promethazine suppositories as well as loperamide while at home with no resolution of his symptoms. His admission temperature was 100.3°F, and he appeared mildly dehydrated. Admission laboratory tests showed a serum sodium level of 136 mEq/L, and he was rehydrated with D5½ normal saline (NS). Four hours into therapy, he became unresponsive with circumoral cyanosis. He was intubated, stabilized with mechanical ventilation, and sedated with lorazepam. Pertinent laboratory values at that time included a serum sodium of level 118 mEq/L. The treatment team began an infusion of NS and gave furosemide. Two hours later his sodium level was 128 mEq/L; 4 hours later it was 130 mEq/L. A chest radiograph showed bilateral diffuse infiltrates consistent …

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Pediatrics
Vol. 99, Issue 5
1 May 1997
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Central Pontine Myelinolysis in a Previously Healthy 4-Year-Old Child With Acute Rotavirus Gastroenteritis
Laura Gregorio, Curtis L. Sutton, Deborah A. Lee
Pediatrics May 1997, 99 (5) 738-742; DOI: 10.1542/peds.99.5.738

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Central Pontine Myelinolysis in a Previously Healthy 4-Year-Old Child With Acute Rotavirus Gastroenteritis
Laura Gregorio, Curtis L. Sutton, Deborah A. Lee
Pediatrics May 1997, 99 (5) 738-742; DOI: 10.1542/peds.99.5.738
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Cited By...

  • Clinical practice guideline on diagnosis and treatment of hyponatraemia
  • Prevention of Hospital-Acquired Hyponatremia: A Case for Using Isotonic Saline
  • Rotavirus Gastroenteritis and Central Nervous System (CNS) Infection: Characterization of the VP7 and VP4 Genes of Rotavirus Strains Isolated from Paired Fecal and Cerebrospinal Fluid Samples from a Child with CNS Disease
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