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American Academy of Pediatrics
Experience and Reason

Recurrent Thrombocytopenic Purpura After Repeated Measles-Mumps-Rubella Vaccination

Vasiliki Vlacha, Edwin N. Forman, Dan Miron and Georges Peter
Pediatrics May 1996, 97 (5) 738-739;
Vasiliki Vlacha
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Edwin N. Forman
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Dan Miron
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Georges Peter
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Abstract

In a review of adverse events associated with childhood vaccines, the Vaccine Safety Committee of the Institute of Medicine (IOM) in 1993 concluded that a causal relationship exists between live-virus measles-mumps-rubella (MMR) vaccination and thrombocytopenia.1 This finding was based on case reports of temporally associated onset of acute thrombocytopenia purpura and MMR vaccination,2,3 population-based surveillance of adverse vaccine reactions in Sweden4 and Finland,5 and demonstrated decreases in platelet concentrations after measles vaccination with the Edmonston B strain.6 The IOM committee also noted that children with prior histories of thrombocytopenia may be at an increased risk of recurrence after MMR vaccination.

  • Received May 19, 1995.
  • Accepted August 3, 1995.
  • Copyright © 1996 by the American Academy of Pediatrics

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Pediatrics
Vol. 97, Issue 5
1 May 1996
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Recurrent Thrombocytopenic Purpura After Repeated Measles-Mumps-Rubella Vaccination
Vasiliki Vlacha, Edwin N. Forman, Dan Miron, Georges Peter
Pediatrics May 1996, 97 (5) 738-739;

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Recurrent Thrombocytopenic Purpura After Repeated Measles-Mumps-Rubella Vaccination
Vasiliki Vlacha, Edwin N. Forman, Dan Miron, Georges Peter
Pediatrics May 1996, 97 (5) 738-739;
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