SECRETORY ANTI-GIARDIA LAMBLIA ANTIBODIES IN HUMAN MILK: PROTECTIVE EFFECT AGAINST DIARRHEA

Abstract

Purpose of the Study. To determine whether anti-Giardia lamblia immunoglobulin A (IgA) antibodies in human milk protect infants from acquisition and/or symptoms associated with giardia infection.

Study Population. One hundred ninety-seven Mexican mother/infant pairs who were part of a larger NIH/Mexican National Institute of Nutrition study.

Methods. The study group was evaluated prospectively from birth on a weekly basis for diarrheal disease and feeding status. Infant stool specimens were collected and tested weekly for pathogenic bacteria, rotavirus, and giardia. Maternal breast milk samples were collected weekly for 1 month postpartum, then monthly thereafter. Milk samples from mothers of infected infants and matched controls were assayed for anti-giardia IgA by ELISA.

Results. Asymptomatic, infected infants ingested higher amounts (P < .05) of anti-Giardia IgA in breast milk when compared with symptomatic infants.