Abstract
We appreciate the comments of Drs Perry and Allison. As they pointed out, the oral administration of prednisone, unlike corticosteroids given intramuscularly or intravenously, is not likely to exacerbate the respiratory distress and hypoxemia of an acutely wheezing child. We would like to emphasize that corticosteroids, regardless of the route of administration, have a delayed onset of action in acute asthma. In our study, had decisions regarding hospitalization been made after 2 hours of care, the hospitalization rates of the prednisone and placebo groups would have been about the same.
- Copyright © 1994 by the American Academy of Pediatrics
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