Those who cannot remember the past are condemned to repeat it.
The Life of Reason
Sodium bicarbonate has long been used in neonatal resuscitation, and recommendations for its use are currently included in guidelines issued as a part of a national program to improve neonatal resuscitation.1 Given our relatively long experience using sodium bicarbonate in neonatal resuscitation, one might assume that the early experimental data on which usage was predicated were extensive and compelling and that modern data continue to support its use.
Sodium bicarbonate was first commercially produced in the late 1950s, and soon thereafter, its use in premature neonates became commonplace, not for treating neonatal asphyxia per se, but rather as a therapy designed to prevent azotemia, hypoglycemia, and elevations in serum potassium levels as well as for correcting metabolic acidosis (the socalled Usher regimen).2
- Received June 12, 1992.
- Accepted August 20, 1992.
- Copyright © 1993 by the American Academy of Pediatrics