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Discover Pediatric Collections on COVID-19 and Racism and Its Effects on Pediatric Health

American Academy of Pediatrics
Article

Thymic Abnormalities in Fetuses Aborted From Human Immunodeficiency Virus Type 1 Seropositive Women

Martine Papiernik, Yves Brossard, Nicole Mulliez, Joelle Roume, Christian Brechot, Francis Barin, Alain Goudeau, Jean-François Bach, Claude Griscelli, Roger Henrion and Rosemay Vazeux
Pediatrics February 1992, 89 (2) 297-301;
Martine Papiernik
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Yves Brossard
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Nicole Mulliez
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Joelle Roume
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Christian Brechot
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Francis Barin
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Alain Goudeau
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Jean-François Bach
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Claude Griscelli
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Roger Henrion
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Rosemay Vazeux
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Abstract

Pathological abnormalities of the thymus were found in 3 of 37 fetuses aborted from human immunodeficiency virus (HIV)-infected mothers. These lesions were located predominantly in the thymic cortex, which contains mostly immature lymphocytes. Areas of focal lymphocyte depletion were infiltrated with CD4+ macrophages and were associated with abnormalities of the epithelial stromal network. No evidence of extensive HIV infection in any of the 37 thymuses was detected by either immunofluorescence or in situ hybridization techniques, although rare cells that expressed HIV antigens were found in 3 fetuses. Although less extensive, this thymic fetopathy was similar to that described in postnatal acquired immunodeficiency syndrome thymuses, strongly suggesting that the lesions were related to HIV infection. Thymic fetopathy might represent the initial injury to the lymphoid system in HIV-infected infants in whom early and severe immunosuppression develops.

  • human immunodeficiency virus type 1
  • fetus
  • thymus gland
  • fetopathy
  • Received January 14, 1991.
  • Accepted June 12, 1991.
  • Copyright © 1992 by the American Academy of Pediatrics

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Pediatrics
Vol. 89, Issue 2
1 Feb 1992
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Thymic Abnormalities in Fetuses Aborted From Human Immunodeficiency Virus Type 1 Seropositive Women
Martine Papiernik, Yves Brossard, Nicole Mulliez, Joelle Roume, Christian Brechot, Francis Barin, Alain Goudeau, Jean-François Bach, Claude Griscelli, Roger Henrion, Rosemay Vazeux
Pediatrics Feb 1992, 89 (2) 297-301;

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Thymic Abnormalities in Fetuses Aborted From Human Immunodeficiency Virus Type 1 Seropositive Women
Martine Papiernik, Yves Brossard, Nicole Mulliez, Joelle Roume, Christian Brechot, Francis Barin, Alain Goudeau, Jean-François Bach, Claude Griscelli, Roger Henrion, Rosemay Vazeux
Pediatrics Feb 1992, 89 (2) 297-301;
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  • Selective Expression of Human Immunodeficiency Virus Nef in Specific Immune Cell Populations of Transgenic Mice Is Associated with Distinct AIDS-Like Phenotypes
  • Induction of Simian AIDS in Infant Rhesus Macaques Infected with CCR5- or CXCR4-Utilizing Simian-Human Immunodeficiency Viruses Is Associated with Distinct Lesions of the Thymus
  • Positive Regulation of CXCR4 Expression and Signaling by Interleukin-7 in CD4+ Mature Thymocytes Correlates with Their Capacity To Favor Human Immunodeficiency X4 Virus Replication
  • Generation of CD3+CD8low Thymocytes in the HIV Type 1-Infected Thymus
  • Impact of Cytokines on Replication in the Thymus of Primary Human Immunodeficiency Virus Type 1 Isolates from Infants
  • Rapid and Irreversible CD4+ T-Cell Depletion Induced by the Highly Pathogenic Simian/Human Immunodeficiency Virus SHIVDH12R Is Systemic and Synchronous
  • Interleukin-7 and infection itself by human immunodeficiency virus 1 favor virus persistence in mature CD4+CD8{-}CD3+ thymocytes through sustained induction of Bcl-2
  • Impaired progenitor cell function in HIV-negative infants of HIV-positive mothers results in decreased thymic output and low CD4 counts
  • T-lymphocyte maturation abnormalities in uninfected newborns and children with vertical exposure to HIV
  • CCR8 on Human Thymocytes Functions as a Human Immunodeficiency Virus Type 1 Coreceptor
  • Thymocyte-Thymic Epithelial Cell Interaction Leads to High-Level Replication of Human Immunodeficiency Virus Exclusively in Mature CD4+ CD8- CD3+ Thymocytes: a Critical Role for Tumor Necrosis Factor and Interleukin-7
  • High-Level Replication of Human Immunodeficiency Virus in Thymocytes Requires NF-{kappa}B Activation through Interaction with Thymic Epithelial Cells
  • Differential Tropism and Replication Kinetics of Human Immunodeficiency Virus Type 1 Isolates in Thymocytes: Coreceptor Expression Allows Viral Entry, but Productive Infection of Distinct Subsets Is Determined at the Postentry Level
  • CXCR4 and CCR5 on Human Thymocytes: Biological Function and Role in HIV-1 Infection
  • Contact with Thymic Epithelial Cells as a Prerequisite for Cytokine-Enhanced Human Immunodeficiency Virus Type 1 Replication in Thymocytes
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