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American Academy of Pediatrics
Article

Cost-Effectiveness of Erythromycin Versus Mupirocin for the Treatment of Impetigo in Children

Teresa Duryea Rice, Anne K. Duggan and Catherine DeAngelis
Pediatrics February 1992, 89 (2) 210-214;
Teresa Duryea Rice
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Anne K. Duggan
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Catherine DeAngelis
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Abstract

A new topical antibiotic, mupirocin, has been found to be as effective as erythromycin for the treatment of impetigo, but concerns about its expense have been raised. This controlled clinical trial sought to compare the cost-effectiveness of erythromycin (E) and mupirocin (M). Ninety-three children, aged 3 months to 16 years, were randomly assigned to receive 10 days of oral erythromycin (n = 46) or topical mupirocin (n = 47). Costs and effects were measured through structured interviews. Cost per case differed significantly by group (E = $56.85; M = $62.30; P < .05) due chiefly to extra visits and medication changes needed by those treated with mupirocin. Erythromycin and mupirocin were equally effective. The likelihood of side effects (E = 43%, M = 22%) approached significance (P < .07); those treated with erythromycin were willing to pay more for a different medicine to avoid the side effects experienced (P < .05). Working parents and school-age children were more likely to alter their daily activities when the patient was taking erythromycin (P < .04). Compliance and parental satisfaction did not differ by treatment group; however, parents of children treated with erythromycin were more likely to prefer the alternate drug regimen. It is concluded that the type of medication prescribed can be based on parental preference because the increased cost of mupirocin is offset by increased side effects and number of schooldays and workdays lost with erythromycin.

  • cost-effectiveness
  • impetigo
  • erythromycin
  • mupirocin
  • Received December 14, 1990.
  • Accepted March 22, 1991.
  • Copyright © 1992 by the American Academy of Pediatrics

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Pediatrics
Vol. 89, Issue 2
1 Feb 1992
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Cost-Effectiveness of Erythromycin Versus Mupirocin for the Treatment of Impetigo in Children
Teresa Duryea Rice, Anne K. Duggan, Catherine DeAngelis
Pediatrics Feb 1992, 89 (2) 210-214;

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Cost-Effectiveness of Erythromycin Versus Mupirocin for the Treatment of Impetigo in Children
Teresa Duryea Rice, Anne K. Duggan, Catherine DeAngelis
Pediatrics Feb 1992, 89 (2) 210-214;
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