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American Academy of Pediatrics
Article

Gastroesophageal Reflux, as Measured By 24-Hour pH Monitoring, in 509 Healthy Infants Screened for Risk of Sudden Infant Death Syndrome

Yvan Vandenplas, Harry Goyvaerts, Rudy Helven and Liliane Sacre
Pediatrics October 1991, 88 (4) 834-840;
Yvan Vandenplas
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Harry Goyvaerts
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Rudy Helven
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Liliane Sacre
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Abstract

Continuous long-term esophageal pH monitoring has become the preferred test to quantify acid gastroesophageal reflux. Because reflux to a limited extent is physiologic, the determination of optimal thresholds to separate normal from abnormal reflux is mandatory. Esophageal pH was measured during 24 hours in 509 healthy thriving infants, aged 3 days to 1 year, using a glass microelectrode with an external reference electrode connected to a portable recorder.

Percentiles of the four parameters studied (reflux index or percent of the investigation time with a pH <4, number of episodes with a pH <4 during 24 hours, number of episodes lasting >5 minutes, the duration of the longest episode (in minutes)) are presented. A percentile curve of the reflux index regarding the age distribution shows that the normal range for the reflux index during the first 12 months of life is about 10% (95 percentile), decreasing from 13% at birth to 8% at 12 months. Application of an age-related percentile curve offers a close-to-reality possibility of data interpretation and illustrates that there is inevitably an overlap of data between normal and abnormal populations, because reflux is a phenomenon occurring to some extent in every human being.

  • gastroesophageal reflux
  • sudden infant death syndrome
  • reflux index
  • pH monitoring
  • Received January 17, 1990.
  • Accepted May 17, 1990.
  • Copyright © 1991 by the American Academy of Pediatrics
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Pediatrics
Vol. 88, Issue 4
1 Oct 1991
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Gastroesophageal Reflux, as Measured By 24-Hour pH Monitoring, in 509 Healthy Infants Screened for Risk of Sudden Infant Death Syndrome
Yvan Vandenplas, Harry Goyvaerts, Rudy Helven, Liliane Sacre
Pediatrics Oct 1991, 88 (4) 834-840;

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Gastroesophageal Reflux, as Measured By 24-Hour pH Monitoring, in 509 Healthy Infants Screened for Risk of Sudden Infant Death Syndrome
Yvan Vandenplas, Harry Goyvaerts, Rudy Helven, Liliane Sacre
Pediatrics Oct 1991, 88 (4) 834-840;
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