Antacid therapy is widely used prophylactically in pediatric intensive care units to prevent stress ulcers. It has also been used in the medical management of gastric bleeding in newborn infants.1,2 Complications of antacid therapy in the newborn infant have included hypotonia, asymptomatic hypermagnesemia without hypocalcemia, as well as aluminum-hydroxide bezoar formation.1-3 This is the first report in which a severe degree of these complications of magnesium-containing antacids is described that includes hypermagnesemia with hypocalcemia and in which a strong case is made against the use of antacid therapy in the treatment of gastric bleeding in very low birth weight infants.
- Received October 31, 1988.
- Accepted March 2, 1989.
- Copyright © 1990 by the American Academy of Pediatrics