An analysis of the antibody titers to toxoplasmosis for 22,845 pregnant women in the Collaborative Perinatal Project was conducted in relation to clinical and laboratory findings in the mothers and children through 7 years of age. More than 900 observations were considered for each mother and child. The major findings were in the children and included a predicted doubling in the frequency of deafness among children born to women with antibody to toxoplasmosis, a predicted 60% increase in microcephaly, and a 30% increase in low IQ (<70) in association with the presence of high maternal antibody titer (256 to 512) to toxoplasma. A serologically defined high-risk group of mothers was identified on the basis of high indirect hemagglutination antibody levels or seroconversions and increased IgM toxoplasma antibody levels (indirect fluorescent antibody ≥32, enzyme-linked immunosorbent assay ≥0.7). Of the 15 pregnancies in this group, two children had congenital toxoplasmosis and three were stillborn.
- indirect hemagglutination
- indirect fluorescent antibody
- enzyme-linked immunosorbent assay
- Received August 13, 1987.
- Accepted October 21, 1987.
- Copyright © 1988 by the American Academy of Pediatrics