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American Academy of Pediatrics
Article

Efficacy Comparison of Oral Rehydration Solutions Containing Either 90 or 75 Millimoles of Sodium per Liter

Daniel Pizarro, Bernardita Castillo, Gloria Posada, Cecilia Lizano and Leonardo Mata
Pediatrics February 1987, 79 (2) 190-195;
Daniel Pizarro
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Bernardita Castillo
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Gloria Posada
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Cecilia Lizano
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Leonardo Mata
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Abstract

In a randomized trial, 62 infants 2 to 35 months of age with dehydration due to acute watery diarrhea were allocated to one of two groups: group A received solution A (World Health Organization-recommended oral rehydration solution), which contained (mmol/L): Na+ 90, K+ 20, Cl- 80, citrate3- 10, and glucose 110; group B received solution B (Pedialyte RS; Abbott Laboratories, North Chicago), which contained (in mmol/L): Na+ 75, K+ 20, Cl- 65, citrate3- 10, and glucose 139. Oral therapy was given until clinical signs of hydration status were normal. During the 48-hour trial, the following laboratory data were collected: blood gases, serum electrolytes, glucose, urea, and creatinine values and sodium and potassium concentrations in stool and urine; serial weights and clinical signs were also reported. Six of the 62 infants, three in each group, required intravenous fluids because of high stool output. Results of clinical outcome and normalization of altered serum electrolyte values were similar in both groups. During the 48-hour trial, eight patients in group A and four in group B had mild, asymptomatic hypernatremia. Pedialyte RS was found to be a safe glucose/electrolyte solution for oral rehydration therapy.

  • dehydration
  • oral rehydration solution
  • Received October 21, 1985.
  • Accepted April 21, 1986.
  • Copyright © 1987 by the American Academy of Pediatrics

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Pediatrics
Vol. 79, Issue 2
1 Feb 1987
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Efficacy Comparison of Oral Rehydration Solutions Containing Either 90 or 75 Millimoles of Sodium per Liter
Daniel Pizarro, Bernardita Castillo, Gloria Posada, Cecilia Lizano, Leonardo Mata
Pediatrics Feb 1987, 79 (2) 190-195;

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Efficacy Comparison of Oral Rehydration Solutions Containing Either 90 or 75 Millimoles of Sodium per Liter
Daniel Pizarro, Bernardita Castillo, Gloria Posada, Cecilia Lizano, Leonardo Mata
Pediatrics Feb 1987, 79 (2) 190-195;
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