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American Academy of Pediatrics
Article

Neonatal Seizures I. Correlation of Prenatal and Perinatal Events with Outcomes

Kenton R. Holden, E. David Mellits and John M. Freeman
Pediatrics August 1982, 70 (2) 165-176;
Kenton R. Holden
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E. David Mellits
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John M. Freeman
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Abstract

A review of 277 newborns with neonatal seizures enrolled in the Collaborative Perinatal Project revealed a mortality of 34.8%. Of the 181 survivors, most followed up to age 7 years, 70% were normal. Thus, despite the fact that seizures are a major indicator of perinatal asphyxia and a predictor of subsequent neurologic deficit, most infants with neonatal seizures who survived did well. Thirteen percent had cerebral palsy, 19% had an IQ <70, and 20% had epilepsy. Thirteen percent of survivors had a combination of mental retardation, cerebral palsy, or epilepsy. A low Apgar score, the need for resuscitation after 5 minutes of age, low birth weight, and the early onset of seizures or prolonged seizures correlated with adverse outcome.

  • Received July 20, 1981.
  • Accepted October 1, 1981.
  • Copyright © 1982 by the American Academy of Pediatrics

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Pediatrics
Vol. 70, Issue 2
1 Aug 1982
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Neonatal Seizures I. Correlation of Prenatal and Perinatal Events with Outcomes
Kenton R. Holden, E. David Mellits, John M. Freeman
Pediatrics Aug 1982, 70 (2) 165-176;

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Neonatal Seizures I. Correlation of Prenatal and Perinatal Events with Outcomes
Kenton R. Holden, E. David Mellits, John M. Freeman
Pediatrics Aug 1982, 70 (2) 165-176;
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  • A Scoring System for Early Prognostic Assessment After Neonatal Seizures
  • Predictive Value of Clinical and EEG Features in the Diagnosis of Stroke and Hypoxic Ischemic Encephalopathy in Neonates With Seizures
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