Abstract
The intent of this communication is to show that the potential for bias, confounding, and/or change in the reported case-control surveys of Reye syndrome (RS) was sufficiently great so as to make any and all inferences pertaining to associations or causality between aspirin and RS highly questionable—or worse—misleading. Further, five lines of recent clinical and scientific evidence question the biologic plausibility of the claimed association.
- Copyright © 1982 by the American Academy of Pediatrics
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