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American Academy of Pediatrics
Article

Treatment of Salmonella Gastroenteritis with Ampicillin, Amoxicillin, or Placebo

John D. Nelson, Helen Kusmiesz, Lula Hinton Jackson and Edythe Woodman
Pediatrics June 1980, 65 (6) 1125-1130;
John D. Nelson
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Helen Kusmiesz
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Lula Hinton Jackson
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Edythe Woodman
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This article has corrections. Please see:

  • ERRATA - July 01, 1980
  • ERRATA - May 01, 1980
  • ERRATA - May 01, 1980
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Abstract

In a randomized, prospective, double-blind study infants and children with uncomplicated Salmonella gastroenteritis were treated with ampicillin (15 patients), amoxicillin (15 patients), or placebo (14 patients). The dosage of antibiotics was 100 mg/kg/day in four equally divided doses given for five days. There was no significant benefit from antibiotic therapy on the duration of diarrhea (means 8.8, 7.3, and 7.2 days, respectively) or on the duration of recovery of Salmonella from stool cultures (means 41.3, 37.0, and 20.9 days, respectively). Bacteriologic relapse was not observed in placebo-treated patients but eight patients given ampicillin (53%) and eight given amoxicillin (53%) had relapse (P = .003). Salmonella isolated in relapse were still susceptible in vitro to the antibiotics. Of the 16 patients with bacteriologic relapse six (38%) had concomitant recurrence of diarrhea. It is concluded that ampicillin or amoxicillin therapy provides no benefit to patients with uncomplicated Salmonella gastroenteritis and substantially increases the risk of bacteriologic and symptomatic relapse.

  • Received July 23, 1979.
  • Accepted September 19, 1979.
  • Copyright © 1980 by the American Academy of Pediatrics

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Pediatrics
Vol. 65, Issue 6
1 Jun 1980
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Treatment of Salmonella Gastroenteritis with Ampicillin, Amoxicillin, or Placebo
John D. Nelson, Helen Kusmiesz, Lula Hinton Jackson, Edythe Woodman
Pediatrics Jun 1980, 65 (6) 1125-1130;

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Treatment of Salmonella Gastroenteritis with Ampicillin, Amoxicillin, or Placebo
John D. Nelson, Helen Kusmiesz, Lula Hinton Jackson, Edythe Woodman
Pediatrics Jun 1980, 65 (6) 1125-1130;
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  • An RNA-centric global view of Clostridioides difficile reveals broad activity of Hfq in a clinically important Gram-positive bacterium
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  • Common harms from amoxicillin: a systematic review and meta-analysis of randomized placebo-controlled trials for any indication
  • The ABC-Type Efflux Pump MacAB Protects Salmonella enterica serovar Typhimurium from Oxidative Stress
  • Peroral Ciprofloxacin Therapy Impairs the Generation of a Protective Immune Response in a Mouse Model for Salmonella enterica Serovar Typhimurium Diarrhea, while Parenteral Ceftriaxone Therapy Does Not
  • Multilocus Sequence Typing Supports the Hypothesis that Cow- and Human-Associated Salmonella Isolates Represent Distinct and Overlapping Populations
  • Ceftiofur-Resistant Salmonella Strains Isolated from Dairy Farms Represent Multiple Widely Distributed Subtypes That Evolved by Independent Horizontal Gene Transfer
  • Characterization of a Laboratory-Derived, High-Level Ampicillin-Resistant Salmonella enterica Serovar Typhimurium Strain That Caused Meningitis in an Infant
  • An evidence and consensus based guideline for acute diarrhoea management
  • Salmonella Excretion after Cessation of Tosufloxacin Therapy in Acute Nontyphoid Salmonella Enterocolitis
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