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American Academy of Pediatrics
Article

Pneumococcal Polysaccharide Immunization in Infants and Children

Morton J. Cowan, Arthur J. Ammann, Diane W. Wara, Virgil M. Howie, Linda Schultz, Nancy Doyle and Michael Kaplan
Pediatrics November 1978, 62 (5) 721-727;
Morton J. Cowan
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Arthur J. Ammann
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Diane W. Wara
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Virgil M. Howie
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Linda Schultz
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Nancy Doyle
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Michael Kaplan
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Abstract

By using indirect hemagglutination antibody responses of normal infants and children to an octavalent pneumococcal vaccine that contained pneumococcal polysaccharide types 1, 3, 6, 7, 14, 18, 19, and 23 were evaluated. By 2 years of age, there was a significant rise in hemagglutination titers to all the polysaccharide types, except type 19. By 6 to 8 months of age, five of the eight types of pneumococcal polysaccharides tested resulted in up to 60% responders and, by 2 years, a significant number responded to all pneumococcal polysaccharide types in the vaccine. Pneumococcal polysaccharide type 3 resulted in a significant antibody response as early as 3 months of age, whereas type 19 never resulted in a significant antibody response. Except for type 3, it seemed that when the other pneumococcal polysaccharides tested produced an antibody response, the degree of response did not subsequently change significantly with increasing age.

The relationship of antibody response to age for pneumococcal polysaccharides is similar to that found for other polysaccharide vaccines. Based on the results of our study, we would recommend immunization with pneumococcal vaccine at 6 months of age with repeat immunization at 2 years of age, especially in high-risk children.

  • Received January 25, 1978.
  • Accepted April 12, 1978.
  • Copyright © 1978 by the American Academy of Pediatrics

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Pediatrics
Vol. 62, Issue 5
1 Nov 1978
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Pneumococcal Polysaccharide Immunization in Infants and Children
Morton J. Cowan, Arthur J. Ammann, Diane W. Wara, Virgil M. Howie, Linda Schultz, Nancy Doyle, Michael Kaplan
Pediatrics Nov 1978, 62 (5) 721-727;

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Pneumococcal Polysaccharide Immunization in Infants and Children
Morton J. Cowan, Arthur J. Ammann, Diane W. Wara, Virgil M. Howie, Linda Schultz, Nancy Doyle, Michael Kaplan
Pediatrics Nov 1978, 62 (5) 721-727;
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