Thirty-three children ranging in age from 5 to 9 years were immunized with varying doses of bivalent A2 (Hong Kong variant) B subunit influenza vaccine. The immunization was given intramuscularly. There were no local or systemic reactions. Thirty-one of 33 children (94%) demonstrated four-fold or greater rises in antibody titer to type A antigen. Twenty-one of 33 (64%) showed four-fold or greater rises to type B antigen. A booster four weeks after immunization produced no significant increase in antibody titer. The subunit influenza vaccine, which is antigenic and well tolerated in children, should be considered for use if routine immunization of children against influenza is deemed desirable.
- Received January 17, 1973.
- Accepted March 19, 1973.
- Copyright © 1973 by the American Academy of Pediatrics