Abstract
The article "Clinically Significant Physiological Changes from Rapidly Administered Hypertonic Solutions: Acute Osmol Poisoning" (Pediatrics, 46:267, 1970) by Kravath, et al. is a valuable addition to the pediatric literature. In a series of interesting experiments the authors again document the potential dangers of rapid intravenous infusions of hypertonic solutions. However, the implication that the experiments so performed are necessarily applicable inthe human organism need some clarification.
In considering the effects of an intravenous infusion in the human, three factors should be considered: (1) osmoiality, (2) volume, and (3) total dose.
- Copyright © 1971 by the American Academy of Pediatrics
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