Newborn infants less than five days of age secrete more cortisol per meter square of body surface area than do older infants, children, and adults. However, their urinary 17-hydroxycorticosteroids corrected for surface area are lower than those of infants 5-20 days of age. The difference between the data on cortisol production and urinary excretion is accounted for by the utilization of different pathways for metabolic disposal of cortisol. Between birth and age 5 days, vaginally delivered and cesarean section babies produce similar amounts of cortisol (18.7 ± 3.7 and 17.2 ± 5.8 mg/M2/24 hr, respectively).
When corrected for body surface area, the CPR of 20 subjects 4 months to 20 years of age and of 28 subjects 21 to 48 years of age fell in a similar range, the mean and standard deviation for the 48 individuals being 11.8 ± 2.5 mg/M2/24 hr.
- Received April 12, 1965.
- Accepted August 2, 1965.
- Copyright © 1966 by the American Academy of Pediatrics