Abstract
Isoantibodies directed against human gamma-globulin were found in children receiving single and repeated injections of gamma-globulin and in those who had received blood transfusions at birth. Nine of 14 children receiving repeated gamma-globulin injections had anti-gamma-globulin antibodies. One-third of all children exposed to gamma-globulin by transfusion or injection, but only 6% of unexposed children had anti-gamma-globulin antibodies. Females appear to have a higher incidence of sensitization than males.
The possibility exists that these antibodies may be implicated in reported anaphylactic reactions to gamma-globulin.
- Received July 30, 1964.
- Accepted October 13, 1964.
- Copyright © 1965 by the American Academy of Pediatrics
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