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American Academy of Pediatrics
Article

THE VALUE OF SERIAL CATECHOLAMINE DETERMINATIONS IN CHILDREN WITH NEUROBLASTOMA

Report of a Case

Mary L. Voorhess and Lytt I. Gardner
Pediatrics August 1962, 30 (2) 241-246;
Mary L. Voorhess
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Lytt I. Gardner
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This article has a correction. Please see:

  • Erratum - January 01, 1971
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Abstract

Urinary catecholamine excretion was measured in a 4-year-old child with neuroblastoma arising from the right adrenal. Initially urinary dopamine and norepinephrine output was high. Because the tumor was inoperable a course of radiation therapy and chemotherapy was given. Following this treatment catecholamine excretion decreased but never reached normal levels. Although there was no clinical evidence of persistent tumor, the elevated urinary output of dopamine and norepinephrine indicated residual neuroblastoma. Therefore surgical exploration was performed and tumor was found overlying the superior pole of the right kidney. After removal of this persistent neuroblastoma the urinary excretion of catecholamines returned to normal and remained at this level. The child has no evidence of recurrent disease and appears healthy. To our knowledge this represents the first reported case wherein the indication for surgical removal of residual neuroblastoma was based solely on elevated output of urinary catecholamines.

  • Copyright © 1962 by the American Academy of Pediatrics

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Pediatrics
Vol. 30, Issue 2
1 Aug 1962
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THE VALUE OF SERIAL CATECHOLAMINE DETERMINATIONS IN CHILDREN WITH NEUROBLASTOMA
Mary L. Voorhess, Lytt I. Gardner
Pediatrics Aug 1962, 30 (2) 241-246;

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THE VALUE OF SERIAL CATECHOLAMINE DETERMINATIONS IN CHILDREN WITH NEUROBLASTOMA
Mary L. Voorhess, Lytt I. Gardner
Pediatrics Aug 1962, 30 (2) 241-246;
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