Skip to main content

Advertising Disclaimer »

Main menu

  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors/Reviewers
    • Submit Manuscript
    • Author Guidelines
    • Reviewer Guidelines
    • Open Access
    • Editorial Policies
  • Content
    • Current Issue
    • Online First
    • Archive
    • Blogs
    • Topic/Program Collections
    • AAP Meeting Abstracts
  • Pediatric Collections
    • COVID-19
    • Racism and Its Effects on Pediatric Health
    • More Collections...
  • AAP Policy
  • Supplements
    • Supplements
    • Publish Supplement
  • Multimedia
    • Video Abstracts
    • Pediatrics On Call Podcast
  • Subscribe
  • Alerts
  • Careers
  • Other Publications
    • American Academy of Pediatrics

User menu

  • Log in
  • Log out
  • My Cart

Search

  • Advanced search
American Academy of Pediatrics

AAP Gateway

Advanced Search

AAP Logo

  • Log in
  • Log out
  • My Cart
  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors/Reviewers
    • Submit Manuscript
    • Author Guidelines
    • Reviewer Guidelines
    • Open Access
    • Editorial Policies
  • Content
    • Current Issue
    • Online First
    • Archive
    • Blogs
    • Topic/Program Collections
    • AAP Meeting Abstracts
  • Pediatric Collections
    • COVID-19
    • Racism and Its Effects on Pediatric Health
    • More Collections...
  • AAP Policy
  • Supplements
    • Supplements
    • Publish Supplement
  • Multimedia
    • Video Abstracts
    • Pediatrics On Call Podcast
  • Subscribe
  • Alerts
  • Careers

Discover Pediatric Collections on COVID-19 and Racism and Its Effects on Pediatric Health

American Academy of Pediatrics
Article

STUDIES IN EXPERIMENTAL HYPERTONICITY

II. Hypertonicity of Body Fluids as a Cause of Acidosis

Juan F. Sotos, Philip R. Dodge and Nathan B. Talbot
Pediatrics August 1962, 30 (2) 180-193;
Juan F. Sotos
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Philip R. Dodge
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nathan B. Talbot
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • Comments
Loading

This article has a correction. Please see:

  • Erratum - January 01, 1971
Download PDF

Abstract

Hypertonicity of body fluids was induced in 23 rabbits by the intravenous injection of solutions of sodium chloride, sodium chloride and bicarbonate, sucrose, or urea at concentrations of about 2,000 mOsm/l. The results obtained suggest that (1) hypertonicity of body fluids can cause disturbances in cellular metabolism, resulting in the formation and release of large quantities of hydrogen ion and the development of severe extracellular metabolic acidosis; (2) with restoration of osmolality toward normal by rehydration, the acidosis is improved; and (3) there is no correlation between the values for plasma pH and the values for sodium and chlorides in plasma, total body water, extracellular and intracellular water, and blood volume.

  • Copyright © 1962 by the American Academy of Pediatrics
PreviousNext
Back to top

Advertising Disclaimer »

In this issue

Pediatrics
Vol. 30, Issue 2
1 Aug 1962
  • Table of Contents
  • Index by author
PreviousNext
Email Article

Thank you for your interest in spreading the word on American Academy of Pediatrics.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
STUDIES IN EXPERIMENTAL HYPERTONICITY
(Your Name) has sent you a message from American Academy of Pediatrics
(Your Name) thought you would like to see the American Academy of Pediatrics web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Request Permissions
Article Alerts
Log in
You will be redirected to aap.org to login or to create your account.
Or Sign In to Email Alerts with your Email Address
Citation Tools
STUDIES IN EXPERIMENTAL HYPERTONICITY
Juan F. Sotos, Philip R. Dodge, Nathan B. Talbot
Pediatrics Aug 1962, 30 (2) 180-193;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
STUDIES IN EXPERIMENTAL HYPERTONICITY
Juan F. Sotos, Philip R. Dodge, Nathan B. Talbot
Pediatrics Aug 1962, 30 (2) 180-193;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Download PDF
Insight Alerts
  • Table of Contents

Jump to section

  • Article
  • Info & Metrics
  • Comments

Related Articles

  • Erratum
  • PubMed
  • Google Scholar

Cited By...

  • Hypernatraemia: diagnosis and management
  • Google Scholar

More in this TOC Section

  • Neonatal SARS-CoV-2 Infections in Breastfeeding Mothers
  • Racial and Ethnic Diversity in Studies Funded Under the Best Pharmaceuticals for Children Act
  • Clinical Impact of a Diagnostic Gastrointestinal Panel in Children
Show more Articles

Similar Articles

  • Journal Info
  • Editorial Board
  • Editorial Policies
  • Overview
  • Licensing Information
  • Authors/Reviewers
  • Author Guidelines
  • Submit My Manuscript
  • Open Access
  • Reviewer Guidelines
  • Librarians
  • Institutional Subscriptions
  • Usage Stats
  • Support
  • Contact Us
  • Subscribe
  • Resources
  • Media Kit
  • About
  • International Access
  • Terms of Use
  • Privacy Statement
  • FAQ
  • AAP.org
  • shopAAP
  • Follow American Academy of Pediatrics on Instagram
  • Visit American Academy of Pediatrics on Facebook
  • Follow American Academy of Pediatrics on Twitter
  • Follow American Academy of Pediatrics on Youtube
  • RSS
American Academy of Pediatrics

© 2021 American Academy of Pediatrics