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American Academy of Pediatrics
Original Article

PREGNANEDIOL EXCRETION IN THE URINE OF NEWBORN MALE INFANTS

Charles C. Roby, William B. Ober and James E. Drorbaugh
Pediatrics June 1956, 17 (6) 877-881;
Charles C. Roby
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William B. Ober
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James E. Drorbaugh
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Abstract

Pregnanediol is found in small quantities in the urine of newborn male infants. It disappears from the urine progressively during the first week of life. The smallest amounts of pregnanediol were found in urines of premature infants born to normal mothers. Considerably higher amounts were found in term infants and in premature infants delivered by cesarean section to diabetic mothers treated with progesterone and stilbestrol throughout pregnancy. The difference between premature infants born to normal mothers and premature infants born to progesterone-treated diabetic mothers is interpreted as indicating that parenterally administered progesterone may, under certain circumstances, cross the placental membrane. Evidence that progesterone is elaborated by the fetus, possibly in the adrenal cortex, is discussed, and the hypothesis offered that the placenta may permit the passage of progesterone in either direction.

  • Received November 21, 1955.
  • Accepted January 9, 1955.
  • Copyright © 1956 by the American Academy of Pediatrics

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Pediatrics
Vol. 17, Issue 6
1 Jun 1956
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PREGNANEDIOL EXCRETION IN THE URINE OF NEWBORN MALE INFANTS
Charles C. Roby, William B. Ober, James E. Drorbaugh
Pediatrics Jun 1956, 17 (6) 877-881;

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PREGNANEDIOL EXCRETION IN THE URINE OF NEWBORN MALE INFANTS
Charles C. Roby, William B. Ober, James E. Drorbaugh
Pediatrics Jun 1956, 17 (6) 877-881;
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More in this TOC Section

  • FACTORS INFLUENCING THE SPREAD OF BETA HEMOLYTIC STREPTOCOCCAL INFECTIONS WITHIN THE FAMILY GROUP
  • CHANGES IN TOTAL CHLORIDE AND ACID-BASE BALANCE IN GASTROENTERITIS FOLLOWING TREATMENT WITH LARGE AND SMALL LOADS OF SODIUM CHLORIDE
  • EVALUATION OF A CONDITIONING DEVICE IN THE TREATMENT OF NOCTURNAL ENURESIS
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