Abstract
Two white sisters of Italian parentage in whom thalassemia-hemoglobin C disease was found, have been presented. This is the third report of such cases and the first in white individuals. This disease produces a microcytic anemia which is usually mild but which may be severe. Splenomegaly may or may not be present.
The presence of large numbers of both microspherocytes and target cells in the blood smear should suggest the possibility of this diagnosis. Confirmatory evidence is found in studies of the blood of family members.
- Copyright © 1956 by the American Academy of Pediatrics
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