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Discover Pediatric Collections on COVID-19 and Racism and Its Effects on Pediatric Health

American Academy of Pediatrics
Article

National Perinatal Hepatitis B Prevention Program: 2009–2017

Alaya Koneru, Nancy Fenlon, Sarah Schillie, Charnetta Williams, Mark K. Weng and Noele Nelson
Pediatrics March 2021, 147 (3) e20201823; DOI: https://doi.org/10.1542/peds.2020-1823
Alaya Koneru
aDivision of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention and
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Nancy Fenlon
bImmunization Services Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
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Sarah Schillie
aDivision of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention and
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Charnetta Williams
bImmunization Services Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
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Mark K. Weng
aDivision of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention and
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Noele Nelson
aDivision of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention and
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Abstract

OBJECTIVES: To assess trends and programmatic outcomes among infants born to hepatitis B surface antigen (HBsAg)–positive women from 2009 to 2017 and case-managed by the Centers for Disease Control and Prevention’s national Perinatal Hepatitis B Prevention Program (PHBPP).

METHODS: We analyzed 2009–2017 annual programmatic reports submitted by 56 US jurisdictions funded through the Centers for Disease Control and Prevention’s PHBPP to assess characteristics of maternal-infant pairs and achievement of objectives of infant hepatitis B postexposure prophylaxis, vaccine series completion, and postvaccination serologic testing (PVST). We compared the number of maternal-infant pairs identified by the program with the number estimated born to HBsAg-positive women from 2009 to 2014 and 2015 to 2017 by using a race and/or ethnicity and maternal country of birth methodology, respectively.

RESULTS: The PHBPP identified 103 825 infants born to HBsAg-positive women from 2009 to 2017, with a range of 10 956 to 12 103 infants annually. Births estimated annually to HBsAg-positive women increased nonsignificantly from 24 804 in 2009 to 26 444 in 2014 (P = .0540) and 20 678 in 2015 to 20 832 in 2017 (P = .8509). The proportion of infants identified annually increased overall from 48.1% to 52.6% (P = .0983). The proportion of case-managed infants receiving postexposure prophylaxis, at least 3 vaccine doses, and PVST increased overall from 94.7% to 97.0% (P = .0952), 83.1% to 84.7% (P = .5377) and 58.8% to 66.8% (P = .0002), respectively.

CONCLUSIONS: The PHBPP has achieved success in managing infants born to HBsAg-positive women and ensuring their immunity to hepatitis B. Nonetheless, strategies are needed to close gaps between the number of infants estimated and identified, increase vaccine series completion, and increase ordering of recommended PVST for all case-managed infants.

  • Accepted December 16, 2020.
  • Copyright © 2021 by the American Academy of Pediatrics

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Pediatrics
Vol. 147, Issue 3
1 Mar 2021
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National Perinatal Hepatitis B Prevention Program: 2009–2017
Alaya Koneru, Nancy Fenlon, Sarah Schillie, Charnetta Williams, Mark K. Weng, Noele Nelson
Pediatrics Mar 2021, 147 (3) e20201823; DOI: 10.1542/peds.2020-1823

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National Perinatal Hepatitis B Prevention Program: 2009–2017
Alaya Koneru, Nancy Fenlon, Sarah Schillie, Charnetta Williams, Mark K. Weng, Noele Nelson
Pediatrics Mar 2021, 147 (3) e20201823; DOI: 10.1542/peds.2020-1823
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