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American Academy of Pediatrics
Article

Invasive Bacterial Infections in Afebrile Infants Diagnosed With Acute Otitis Media

Son H. McLaren, Andrea T. Cruz, Kenneth Yen, Matthew J. Lipshaw, Kelly R. Bergmann, Rakesh D. Mistry, Colleen K. Gutman, Fahd A. Ahmad, Christopher M. Pruitt, Graham C. Thompson, Matthew D. Steimle, Xian Zhao, Abigail M. Schuh, Amy D. Thompson, Holly R. Hanson, Stacey L. Ulrich, James A. Meltzer, Jennifer Dunnick, Suzanne M. Schmidt, Lise E. Nigrovic, Muhammad Waseem, Roberto Velasco, Samina Ali, Danielle L. Cullen, Borja Gomez, Ron L. Kaplan, Kajal Khanna, Jonathan Strutt, Paul L. Aronson, Ankita Taneja, David C. Sheridan, Carol C. Chen, Amanda L. Bogie, Aijin Wang, Peter S. Dayan and ON BEHALF OF THE PEDIATRIC EMERGENCY MEDICINE COLLABORATIVE RESEARCH COMMITTEE
Pediatrics January 2021, 147 (1) e20201571; DOI: https://doi.org/10.1542/peds.2020-1571
Son H. McLaren
aDepartment of Emergency Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York;
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Andrea T. Cruz
bDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas;
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Kenneth Yen
cDepartment of Pediatrics, University of Texas Southwestern, Dallas, Texas;
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Matthew J. Lipshaw
dDivision of Emergency Medicine, Cincinnati Children’s Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio;
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Kelly R. Bergmann
eDepartment of Emergency Services, Children’s Minnesota, Minneapolis, Minnesota;
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Rakesh D. Mistry
fDepartment of Pediatrics, School of Medicine, University of Colorado and Children’s Hospital Colorado, Aurora, Colorado;
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Colleen K. Gutman
gDepartment of Pediatrics, Emory University, Atlanta, Georgia;
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Fahd A. Ahmad
hDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri;
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Christopher M. Pruitt
iDepartment of Pediatrics, University of Alabama, Birmingham, Alabama;
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Graham C. Thompson
jDepartment of Pediatrics, University of Calgary and Alberta Children’s Hospital, Calgary, Alberta, Canada;
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Matthew D. Steimle
kDepartment of Pediatrics, Division of Pediatric Emergency Medicine, School of Medicine, University of Utah, Salt Lake City, Utah;
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Xian Zhao
lDepartment of Pediatrics, Division of Emergency Medicine, Children’s National Health System, Washington, DC;
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Abigail M. Schuh
mDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin;
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Amy D. Thompson
nDepartment of Pediatrics, Alfred I. duPont Hospital for Children, Wilmington, Delaware;
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Holly R. Hanson
oDepartment of Pediatrics, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, Tennessee;
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Stacey L. Ulrich
pDepartment of Pediatrics, Rady Children’s Hospital San Diego, San Diego, California;
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James A. Meltzer
qDepartment of Pediatrics, Jacobi Medical Center, Bronx, New York;
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Jennifer Dunnick
rDepartment of Pediatrics, University of Pittsburgh Medical Center Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania;
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Suzanne M. Schmidt
sDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois;
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Lise E. Nigrovic
tDivision of Emergency Medicine, Boston Children’s Hospital, Boston, Massachusetts;
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Muhammad Waseem
uDepartment of Pediatrics and Emergency Medicine, Lincoln Medical Center, Bronx, New York;
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Roberto Velasco
vPediatric Emergency Unit, Rio Hortega University Hospital, Valladolid, Spain;
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Samina Ali
wDepartment of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada;
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Danielle L. Cullen
xDepartment of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania;
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Borja Gomez
yPediatric Emergency Department, Cruces University Hospital, Bilbao, Spain;
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Ron L. Kaplan
zDepartment of Pediatrics, School of Medicine, University of Washington and Seattle Children's Hospital, Seattle, Washington;
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Kajal Khanna
aaDepartment of Emergency Medicine, Stanford University, Stanford, California;
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Jonathan Strutt
abDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota;
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Paul L. Aronson
acDepartments of Pediatrics and Emergency Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut;
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Ankita Taneja
adDepartment of Pediatrics, University of Florida, Jacksonville, Jacksonville, Florida;
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David C. Sheridan
aeDepartment of Emergency Medicine and Pediatrics, Oregon Health and Science University, Portland, Oregon;
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Carol C. Chen
afDepartment of Emergency Medicine, University of California San Francisco, San Francisco, California;
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Amanda L. Bogie
agDepartment of Pediatrics, University of Oklahoma, Oklahoma City, Oklahoma; and
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Aijin Wang
ahDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York
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Peter S. Dayan
aDepartment of Emergency Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York;
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Article Information

vol. 147 no. 1 e20201571
DOI 
https://doi.org/10.1542/peds.2020-1571
PubMed 
33288730

Published By 
American Academy of Pediatrics
Print ISSN 
0031-4005
Online ISSN 
1098-4275
History 
  • Accepted September 24, 2020
  • Published online January 1, 2021.

Article Versions

  • previous version (December 7, 2020 - 00:05).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2021 by the American Academy of Pediatrics

Author Information

  1. Son H. McLaren, MD, MSa,
  2. Andrea T. Cruz, MD, MPHb,
  3. Kenneth Yen, MD, MSc,
  4. Matthew J. Lipshaw, MD, MSd,
  5. Kelly R. Bergmann, DOe,
  6. Rakesh D. Mistry, MD, MSf,
  7. Colleen K. Gutman, MDg,
  8. Fahd A. Ahmad, MD, MSCIh,
  9. Christopher M. Pruitt, MDi,
  10. Graham C. Thompson, MDj,
  11. Matthew D. Steimle, DOk,
  12. Xian Zhao, MDl,
  13. Abigail M. Schuh, MD, MMHPEm,
  14. Amy D. Thompson, MDn,
  15. Holly R. Hanson, MD, MSo,
  16. Stacey L. Ulrich, MDp,
  17. James A. Meltzer, MD, MSq,
  18. Jennifer Dunnick, MD, MPHr,
  19. Suzanne M. Schmidt, MDs,
  20. Lise E. Nigrovic, MD, MPHt,
  21. Muhammad Waseem, MD, MSu,
  22. Roberto Velasco, MD, PhDv,
  23. Samina Ali, MDw,
  24. Danielle L. Cullen, MD, MPH, MSHPx,
  25. Borja Gomez, MD, PhDy,
  26. Ron L. Kaplan, MDz,
  27. Kajal Khanna, MD, JDaa,
  28. Jonathan Strutt, MDab,
  29. Paul L. Aronson, MD, MHSac,
  30. Ankita Taneja, MDad,
  31. David C. Sheridan, MDae,
  32. Carol C. Chen, MD, MPHaf,
  33. Amanda L. Bogie, MDag,
  34. Aijin Wang, MSah,
  35. Peter S. Dayan, MD, MSca,
  36. ON BEHALF OF THE PEDIATRIC EMERGENCY MEDICINE COLLABORATIVE RESEARCH COMMITTEE
  1. aDepartment of Emergency Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York;
  2. bDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas;
  3. cDepartment of Pediatrics, University of Texas Southwestern, Dallas, Texas;
  4. dDivision of Emergency Medicine, Cincinnati Children’s Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio;
  5. eDepartment of Emergency Services, Children’s Minnesota, Minneapolis, Minnesota;
  6. fDepartment of Pediatrics, School of Medicine, University of Colorado and Children’s Hospital Colorado, Aurora, Colorado;
  7. gDepartment of Pediatrics, Emory University, Atlanta, Georgia;
  8. hDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri;
  9. iDepartment of Pediatrics, University of Alabama, Birmingham, Alabama;
  10. jDepartment of Pediatrics, University of Calgary and Alberta Children’s Hospital, Calgary, Alberta, Canada;
  11. kDepartment of Pediatrics, Division of Pediatric Emergency Medicine, School of Medicine, University of Utah, Salt Lake City, Utah;
  12. lDepartment of Pediatrics, Division of Emergency Medicine, Children’s National Health System, Washington, DC;
  13. mDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin;
  14. nDepartment of Pediatrics, Alfred I. duPont Hospital for Children, Wilmington, Delaware;
  15. oDepartment of Pediatrics, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, Tennessee;
  16. pDepartment of Pediatrics, Rady Children’s Hospital San Diego, San Diego, California;
  17. qDepartment of Pediatrics, Jacobi Medical Center, Bronx, New York;
  18. rDepartment of Pediatrics, University of Pittsburgh Medical Center Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania;
  19. sDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois;
  20. tDivision of Emergency Medicine, Boston Children’s Hospital, Boston, Massachusetts;
  21. uDepartment of Pediatrics and Emergency Medicine, Lincoln Medical Center, Bronx, New York;
  22. vPediatric Emergency Unit, Rio Hortega University Hospital, Valladolid, Spain;
  23. wDepartment of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada;
  24. xDepartment of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania;
  25. yPediatric Emergency Department, Cruces University Hospital, Bilbao, Spain;
  26. zDepartment of Pediatrics, School of Medicine, University of Washington and Seattle Children's Hospital, Seattle, Washington;
  27. aaDepartment of Emergency Medicine, Stanford University, Stanford, California;
  28. abDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota;
  29. acDepartments of Pediatrics and Emergency Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut;
  30. adDepartment of Pediatrics, University of Florida, Jacksonville, Jacksonville, Florida;
  31. aeDepartment of Emergency Medicine and Pediatrics, Oregon Health and Science University, Portland, Oregon;
  32. afDepartment of Emergency Medicine, University of California San Francisco, San Francisco, California;
  33. agDepartment of Pediatrics, University of Oklahoma, Oklahoma City, Oklahoma; and
  34. ahDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York
  1. Drs McLaren and Dayan conceptualized and designed the study, designed the data collection instruments, coordinated and supervised data collection and transfer from other sites, performed data analyses, drafted the initial manuscript, and reviewed and revised the manuscript; Dr Cruz participated in the study design, collected local data, and reviewed and revised the manuscript; Drs Yen, Lipshaw, Bergmann, Mistry, Gutman, Ahmad, Pruitt, Thompson, Steimle, Zhao, Schuh, Thompson, Hanson, Ulrich, Meltzer, Dunnick, Schmidt, Nigrovic, Waseem, Velasco, Ali, Cullen, Gomez, Kaplan, Khanna, Strutt, Aronson, Taneja, Sheridan, Chen, and Bogie collected data at their sites and critically reviewed and revised the manuscript; Ms Wang performed data analysis and reviewed and revised the manuscript; and all authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

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Invasive Bacterial Infections in Afebrile Infants Diagnosed With Acute Otitis Media
Son H. McLaren, Andrea T. Cruz, Kenneth Yen, Matthew J. Lipshaw, Kelly R. Bergmann, Rakesh D. Mistry, Colleen K. Gutman, Fahd A. Ahmad, Christopher M. Pruitt, Graham C. Thompson, Matthew D. Steimle, Xian Zhao, Abigail M. Schuh, Amy D. Thompson, Holly R. Hanson, Stacey L. Ulrich, James A. Meltzer, Jennifer Dunnick, Suzanne M. Schmidt, Lise E. Nigrovic, Muhammad Waseem, Roberto Velasco, Samina Ali, Danielle L. Cullen, Borja Gomez, Ron L. Kaplan, Kajal Khanna, Jonathan Strutt, Paul L. Aronson, Ankita Taneja, David C. Sheridan, Carol C. Chen, Amanda L. Bogie, Aijin Wang, Peter S. Dayan, ON BEHALF OF THE PEDIATRIC EMERGENCY MEDICINE COLLABORATIVE RESEARCH COMMITTEE
Pediatrics Jan 2021, 147 (1) e20201571; DOI: 10.1542/peds.2020-1571

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Invasive Bacterial Infections in Afebrile Infants Diagnosed With Acute Otitis Media
Son H. McLaren, Andrea T. Cruz, Kenneth Yen, Matthew J. Lipshaw, Kelly R. Bergmann, Rakesh D. Mistry, Colleen K. Gutman, Fahd A. Ahmad, Christopher M. Pruitt, Graham C. Thompson, Matthew D. Steimle, Xian Zhao, Abigail M. Schuh, Amy D. Thompson, Holly R. Hanson, Stacey L. Ulrich, James A. Meltzer, Jennifer Dunnick, Suzanne M. Schmidt, Lise E. Nigrovic, Muhammad Waseem, Roberto Velasco, Samina Ali, Danielle L. Cullen, Borja Gomez, Ron L. Kaplan, Kajal Khanna, Jonathan Strutt, Paul L. Aronson, Ankita Taneja, David C. Sheridan, Carol C. Chen, Amanda L. Bogie, Aijin Wang, Peter S. Dayan, ON BEHALF OF THE PEDIATRIC EMERGENCY MEDICINE COLLABORATIVE RESEARCH COMMITTEE
Pediatrics Jan 2021, 147 (1) e20201571; DOI: 10.1542/peds.2020-1571
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