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American Academy of Pediatrics
Article

Three-Year Outcomes After Brief Treatment of Substance Use and Mood Symptoms

Sujaya Parthasarathy, Andrea H. Kline-Simon, Ashley Jones, Lauren Hartman, Katrina Saba, Constance Weisner and Stacy Sterling
Pediatrics January 2021, 147 (1) e2020009191; DOI: https://doi.org/10.1542/peds.2020-009191
Sujaya Parthasarathy
aDivision of Research, Kaiser Permanente Northern California, Oakland, California; and
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Andrea H. Kline-Simon
aDivision of Research, Kaiser Permanente Northern California, Oakland, California; and
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Ashley Jones
aDivision of Research, Kaiser Permanente Northern California, Oakland, California; and
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Lauren Hartman
bThe Permanente Medical Group, Oakland, California
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Katrina Saba
bThe Permanente Medical Group, Oakland, California
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Constance Weisner
aDivision of Research, Kaiser Permanente Northern California, Oakland, California; and
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Stacy Sterling
aDivision of Research, Kaiser Permanente Northern California, Oakland, California; and
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    FIGURE 1

    Adolescents in primary care reporting both substance use and mood problems.

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    TABLE 1

    Comparison Between Adolescents With Both Past-Year Substance Use and Recent Mood Symptoms and Those Without (n = 1871)

    Full SampleAdolescents With Past-Year Substance Use and Recent Mood Problems (n = 289)Adolescents With Either Past-Year Substance Use or Recent Mood Problems (n = 1582)P
    Demographics, n (%)
     Women199 (68.9)842(53.2)<.01
    Race and ethnicity, n (%)
     White65 (22.5)461 (29.1).15
     Black111 (38.4)525 (33.2)—
     Asian American30 (10.4)189 (11.9)—
     Hispanic62 (21.5)332 (21.0)—
     Other5 (1.7)20 (1.3)—
    Age, mean (SD)16.1 (0.08)15.8 (0.04)<.01
    Comorbidity in year before, n (%)
     Any depression diagnosis53 (18.3)96 (6.1)<.01
     Any substance use diagnosis8 (2.8)48 (3.0).91
     At least 1 chronic conditiona52 (18.0)284 (18.0).99
    • —, not applicable.

    • ↵a Chronic conditions included asthma, arthritis, diabetes, irritable bowel syndrome, migraine, rhinitis, and sinusitis.

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    TABLE 2

    Demographic Characteristics of Analytic Sample by SBIRT Group (n = 289)

    Analytic SampleSBIRT Group (n = 185)UC (n = 104)P
    Demographics, n (%)
     Women134 (72.4)65 (62.5).08
    Race ethnicity, n (%)
     White37 (20)28 (26.9).47
     Black72 (38.9)39 (37.5)—
     Asian American21 (11.4)9 (8.7)—
     Hispanic42 (22.7)20 (19.2)—
     Other2 (1)3 (2.9)—
    Age, mean (SD)16.1 (0.1)16.1 (0.1).87
    • —, not applicable.

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    TABLE 3

    Unadjusted Prevalence of Depression, Substance Use and Medical Diagnoses, and Health Care Use Over Time

    1 y Prescreening1 y Prescreening1 y Prescreening
    SBIRT Group (n = 185)UC (n = 104)PSBIRT Group (n = 185)UC (n = 104)PSBIRT Group (n = 185)UC (n = 104)P
    Comorbidity, n (%)
     Any depression diagnosis30 (16.2)23 (21.9).217 (3.8)12 (11.4).0131 (16.8)29 (27.6).03
     Any substance use diagnosis5 (2.7)3 (2.9).934 (2.2)3 (2.9).7022 (11.9)21 (20.0).06
     Any chronic conditiona28 (15.1)24 (22.9).0911 (5.9)14 (13.3).0364 (34.6)43 (41.0).25
    Any use, n (%)
     Hospitalization2 (1.1)0 (0.0).290 (0.0)1 (1.0).186 (3.2)7 (6.7).17
     Any outpatient142 (76.8)80 (76.2).9752 (28.1)38 (36.2).14161 (87.0)92 (87.6).72
      ED42 (22.7)27 (25.7).5311 (5.9)11 (10.5).1567 (36.2)47 (44.8).13
      Specialty substance use treatment4 (2.2)0 (0.0).131 (0.5)0 (0.0).458 (4.3)8 (7.6).23
      Psychiatry46 (24.9)23 (21.9).6012 (6.5)10 (9.5).3438 (20.5)27 (25.7).29
      Primary care130 (70.3)76 (72.4).6146 (24.9)33 (31.4).21157 (84.9)88 (83.8).95
    No. visits, mean (SE)
     All outpatient6.55 (0.81)5.63 (0.01).501.51 (0.31)2.01 (0.43).3512.11 (1.76)13.13 (1.73).68
      ED0.31 (0.05)0.39 (0.08).350.08 (0.02)0.17 (0.06).140.78 (0.11)1.17 (0.22).12
      Specialty substance use treatment0.32 (0.22)0.00 (0.00).150.14 (0.14)0.00 (0.00).322.59 (1.18)2.05 (1.22).75
      Psychiatry2.56 (0.53)2.52 (0.87).970.36 (0.12)0.61 (0.25).392.04 (0.46)2.60 (0.82).55
      Primary care1.97 (0.17)1.78 (0.20).490.68 (0.12)0.86 (0.18).415.12 (0.44)5.28 (0.51).82
    • ↵a Any chronic condition included asthma, arthritis, diabetes, irritable bowel syndrome, migraine, rhinitis, and sinusitis.

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    TABLE 4

    Multivariate Analyses of Depression, Substance Use, and Chronic Medical Diagnoses 1 and 3 Years Postscreening

    1-y Postscreening3-y Postscreening
    OR95% Confidence LimitsPOR95% Confidence LimitsP
    Depression diagnosis
     SBIRT group (reference = UC)0.310.110.87**0.510.280.94**
     Female (reference = male)2.640.6810.28—2.271.074.81**
     Age1.070.711.63—0.840.661.06—
     Race and ethnicity (reference = white)
      Asian American0.210.022.09—0.300.071.22—
      Black0.790.252.52—0.730.341.59—
      Hispanic0.260.051.39—0.720.311.67—
      Unknown or missing0.390.043.69—0.450.111.85—
     Previous depression diagnosis6.652.3818.54**3.131.576.26**
    Substance use diagnosisa
     SBIRT group (reference = UC)N/AN/AN/A—0.460.230.92**
     Female (reference = male)N/AN/AN/A—1.690.773.71—
     AgeN/AN/AN/A—1.240.951.64—
     Race and ethnicity (reference = white)N/AN/AN/A
      Asian AmericanN/AN/AN/A—0.160.011.66—
      BlackN/AN/AN/A—1.090.422.85—
      HispanicN/AN/AN/A—1.890.705.07—
      Unknown or missingN/AN/AN/A—1.790.457.06—
     Previous substance use diagnosisN/AN/AN/A—13.082.6365.07**
    Chronic medical diagnosis
     SBIRT group (reference = UC)0.480.211.14—0.850.491.46—
     Female (reference = male)0.890.362.16—1.400.782.49—
     Age0.970.701.34—0.850.701.04—
     Race and ethnicity (reference = white)
      Asian American0.270.032.33—0.560.191.63—
      Black0.570.201.59—0.830.411.68—
      Hispanic0.530.161.78—0.720.341.56—
      Unknown or missing0.440.053.86—0.600.191.96—
      Previous medical condition2.701.076.78**6.883.4213.82**
    • Any chronic condition included asthma, arthritis, diabetes, irritable bowel syndrome, migraine, rhinitis, and sinusitis. N/A , not applicable; —, not significant.

    • ↵a One-year postscreening multivariate analyses could not be performed because of quasi separation of the data.

    • ↵** P < .05.

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    TABLE 5

    Multivariate Analyses of Health Services Use Over 3 Years Postscreening

    Rate Ratio95% CIP
    ED use
     SBIRT group (reference = UC)0.650.440.97**
     Female (reference = male)1.821.182.80**
     Age1.181.021.36**
     Race and ethnicity
      Asian American0.270.100.72**
      Black1.300.772.21—
      Hispanic1.290.732.27—
      Unknown or missing1.120.492.54—
    Psychiatric treatment use
     SBIRT group (reference = UC)1.000.551.85—
     Female (reference = male)1.410.762.62—
     Age0.700.570.87**
     Race and ethnicity (reference = white)
      Asian American0.200.060.63**
      Black0.320.140.70**
      Hispanic0.430.181.04*
      Unknown or missing0.930.273.17—
    Primary care use
     SBIRT group (reference = UC)0.890.691.15—
     Female (reference = male)1.641.262.14**
     Age0.920.841.01*
     Race and ethnicity (reference = white)
      Asian American0.850.531.37—
      Black1.090.781.50—
      Hispanic1.100.771.57—
      Unknown or missing1.300.772.17—
    All outpatient use
     SBIRT group (reference = UC)0.890.651.22—
     Female (reference = male)1.220.891.69—
     Age0.910.821.01*
     Race and ethnicity (reference = white)
      Asian American0.460.250.83**
      Black0.590.390.88**
      Hispanic1.110.711.74—
      Unknown or missing1.390.451.61—
    • —, not significant.

    • ↵* P < .10.

    • ↵** P < .05.

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Three-Year Outcomes After Brief Treatment of Substance Use and Mood Symptoms
Sujaya Parthasarathy, Andrea H. Kline-Simon, Ashley Jones, Lauren Hartman, Katrina Saba, Constance Weisner, Stacy Sterling
Pediatrics Jan 2021, 147 (1) e2020009191; DOI: 10.1542/peds.2020-009191

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Three-Year Outcomes After Brief Treatment of Substance Use and Mood Symptoms
Sujaya Parthasarathy, Andrea H. Kline-Simon, Ashley Jones, Lauren Hartman, Katrina Saba, Constance Weisner, Stacy Sterling
Pediatrics Jan 2021, 147 (1) e2020009191; DOI: 10.1542/peds.2020-009191
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