Long-term Outcomes of Individuals With Metabolic Diseases Identified Through Newborn Screening

^aDivision of Child Neurology and Metabolic Medicine and Dietmar Hopp Metabolic Center, Center for Child and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany;
^bDivision of Pediatric Neurology, University Children’s Hospital Frankfurt, Frankfurt, Germany;
^cChildren’s Hospital Reutlingen, Klinikum am Steinenberg Reutlingen, Reutlingen, Germany;
^dDepartment of General Pediatrics, Adolescent Medicine and Neonatology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany;
^eVilla Metabolica, Center for Pediatric and Adolescent Medicine, University Medical Center Mainz, Mainz, Germany;
^fDepartment of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children’s Hospital, Heinrich Heine University Düsseldorf, Düsseldorf, Germany;
^gInstitute of Child Nutrition, Max Rubner-Institut, Karlsruhe, Germany;
^hDepartment of Pediatric and Adolescent Medicine, Medical School, Ulm University, Ulm, Germany; and
ⁱCenter for Child and Adolescent Medicine, University Hospital Greifswald, Greifswald, Germany

Dr Mütze conceptualized and designed the study and the data collection instruments, coordinated and supervised data collection, evaluated and interpreted data, drafted the initial manuscript, reviewed and revised the final manuscript, had full access to all the data in the study, and had final responsibility for the decision to submit for publication; Dr Kölker conceptualized and designed the study and the data collection instruments, coordinated and supervised data collection, evaluated and interpreted data, drafted the initial manuscript, and reviewed and revised the final manuscript; Dr Garbade conducted the statistical analyses and critically reviewed and revised the manuscript for important intellectual content; Drs Lindner and Gramer designed the study, collected newborn screening and clinical data, and critically reviewed and revised the manuscript for important intellectual content; Mr Gleich conducted data collection and management and critically reviewed and revised the manuscript for important intellectual content; Drs Freisinger, Hennermann, Ensenauer, Leichsenring, Grünert, Thimm, and Zirnbauer collected the data at their study site and reviewed and critically revised the manuscript for important intellectual content; Drs Hörster, Grohmann-Held, and Boy collected data at the study center and reviewed and revised the manuscript critically for important intellectual content; Dr Fang-Hoffmann collected newborn screening data and reviewed and critically revised the manuscript for important intellectual content; Dr Burgard designed the study, collected clinical data, conducted psychological tests, and critically reviewed and revised the manuscript for important intellectual content; Dr Walter collected clinical data, conducted psychological tests, and critically reviewed and revised the manuscript for important intellectual content; Dr Hoffmann conceptualized and designed the study and critically reviewed and revised the manuscript for important intellectual content; and all authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

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